Louisville vs. Stanford odds, picks and predictions

Analyzing Saturday’s Louisville at Stanford odds and lines, with college football expert picks, predictions and best bets.

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The No. 24 Louisville Cardinals (6-3, 4-2 ACC) meet the Stanford Cardinal (2-7, 1-5) at Stanford Stadium Saturday. Kickoff is at 3:30 p.m. ET (ACC Network). Below, we look at Louisville vs. Stanford odds from BetMGM Sportsbook’s college football odds and make our expert college football picks and predictions.

Louisville secured its third win in the last 4 games, defeating the Clemson Tigers 33-21 as 10.5-point road underdogs while the Under 62.5 hit. RB Isaac Brown led the way with 151 yards on 20 carries and a TD.

Stanford has lost 6 straight games, with their latest defeat 59-28 at the N.C. State Wolfpack. They failed to cover as 9.5-point underdogs while the Over 46.5 hit. Stanford’s defense allowed 281 rushing yards and 5 TDs. QB Ashton Daniels was the lone bright spot, rushing for 129 yards and 2 TDs on 11 carries.

– RankingsUS LBM Coaches Poll, conducted by the American Football Coaches Association and USA TODAY Sports

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Louisville vs. Stanford odds

Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list of college football odds. Lines last updated Friday at 1:43 p.m. ET.

  • Moneyline (ML): Louisville -1400 (bet $1,400 to win $100) | Stanford +825 (bet $100 to win $825)
  • Against the spread (ATS): Louisville -20.5 (-110) | Stanford +20.5 (-110)
  • Over/Under (O/U): 57.5 (O: -110 | U: -110)

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Louisville vs. Stanford picks and predictions

Prediction

Louisville 41, Stanford 14

Moneyline

PASS.

Louisville (-1400) will win this game comfortably, which is why you should take your wager to the spread.

Against the spread

BET LOUISVILLE -20.5 (-110).

Louisville enters this game after a bye week and riding a 2-game win streak, including a road victory over Clemson. Meanwhile, Stanford has dropped 6 straight games, with a defense that has allowed 40+ points in 3 of its last 4 outings. The Cardinal have also failed to cover in their last 10 November home games. Louisville has covered in 5 of its last 6 November road games against unranked teams. Stanford’s defense gives up an average of 34.6 points per game, and with recent struggles, it’s hard to back them here. Take Louisville to win on the road.

Over/Under

BET UNDER 57.5 (-110).

Louisville and Stanford are trending in opposite directions for totals, with the Cardinals hitting the over in 6 of 9 games and the Cardinal hitting the under in 6 of 9. The line is set at 58.5, reflecting expectations for Louisville to dominate and Stanford to control the clock. Stanford has gone under in 2 of its last 3 games, while Louisville has gone 2-2 in their last 4. With Stanford focusing on a run-heavy offense and Louisville not needing a huge margin for the playoffs, the Over seems unlikely. Louisville’s focus will shift to securing a bowl game rather than running up the score.

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