Los Angeles Rams at Buffalo Bills odds, picks and best bets

Previewing the Week 3 matchup between the Rams and Bills betting odds and lines, with NFL betting picks, tips and best bets.

The Los Angeles Rams (2-0) and Buffalo Bills (2-0) will square off on Sunday afternoon in a matchup between two undefeated teams. Kickoff is set for 1 p.m. ET from Bills Stadium in Buffalo.

Rams at Bills betting odds and lines

Odds via BetMGM; access USA TODAY Sports’ betting odds for a full list. Lines last updated Friday at 12:30 p.m. ET.

  • Money line: Rams +105 (bet $100, win $105) | Bills -125 (Bet $125, win $100)
  • Against the Spread/ATS: Rams +2 (-110) | Bills -2 (-110)
  • Over/Under: 46.5 (O: -110, U: -110)

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Rams at Bills game notes

  • The Rams covered the spread in each of their first two games, being 1.5-point underdogs in each.
  • The Bills are only 1-4 ATS in their last five games dating back to last season, including 1-1 this year.
  • The Rams are 5-0 in 1 p.m. ET games in the Eastern Time Zone since Sean McVay took over in 2017, scoring 30 points in each game.
  • Josh Allen and the Bills lead the league in passing yards, while the Rams rank third in rushing yards.
  • The Bills are 7-5 all time against the Rams, with their last meeting coming in 2016.

Rams at Bills key injuries

Rams

  • LG Joe Noteboom (calf) out
  • RB Cam Akers (ribs) DNP Thursday
  • CB Darious Williams (ankle) limited in practice Thursday

Bills

  • RB Zack Moss (toe) out
  • TE Dawson Knox (concussion) out
  • WR John Brown (foot) questionable/limited in practice Thursday
  • DT Ed Oliver (knee) questionable/limited in practice Thursday
  • LB Tremaine Edmunds (shoulder) questionable/limited in practice Thursday
  • LB Matt Milano (hamstring) questionable/limited in practice Thursday
  • CB Taron Johnson (groin) questionable/limited in practice Thursday

Rams at Bills: Odds, betting lines, picks and prediction

Prediction

Rams 26, Bills 24

Moneyline (?)

The Bills come into this one as the home favorites with the Rams once again traveling across the country for the second week in a row. It didn’t bother them last week and it hasn’t in the last three seasons, which limits the legitimacy of a home-field advantage for Buffalo – especially with no fans in attendance.

I like the RAMS (+105) in this one simply based on the coaching prowess of Sean McVay, who will draw up a game plan to counter the Bills’ stout defense.

Against the Spread (?)

Despite only going 9-7 last season, the Rams were good against the spread down the stretch. They’re 6-3-1 ATS in their last 10 games dating back to last season and covered in each of the first two weeks this year.

Getting 2 points is a bonus because the Rams can play with anyone and should at least keep it close with Buffalo, if not win outright. Take the RAMS +2 (-110).

Over/Under (?)

The Over/Under (46.5) is difficult to predict in this game because both offenses can put up points in a hurry, but their defenses are also among the best in the league. QB Jared Goff and QB Josh Allen have both been susceptible to turnovers in recent years and it’s reasonable to expect each to have at least one giveaway in this game.

I’m taking the OVER 46.5 (-110) and betting that both offenses turn this one into a shootout.

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