The Arizona Cardinals found some success against the vaunted 49ers defense the last time these clubs squared off.

That defense had a strong showing against the Seahawks on Monday night, and with so many injuries on offense, they’ll need another shut-down outing vs. the Cardinals on Sunday. Here are three keys for the 49ers to adjust to, and shut down Kliff Kingsbury’s spread attack:

1. Stop the run

Typically getting a pass-heavy team out of its element and running the ball is a decent strategy. That’s not the case for Kingsbury’s offense though. Arizona ran roughshod over the 49ers on Halloween without either of its top two running backs. Now top running back David Johnson will be back in the lineup, and San Francisco has to ensure Arizona isn’t getting ahead of the sticks with their run game. They become much more difficult to stop if they do.

2. No big plays

An 88-yard touchdown catch from rookie Andy Isabella was a key play in the last meeting between these clubs. The 49ers’ defense wasn’t having a particularly bad game until multiple missed tackles and bad angles allowed the speedy Isabella to score. San Francisco can’t allow another devastating big play like that.

3. Set the tempo

Arizona had a ton of success with an up tempo offense the last time these teams played. The 49ers can limit some of that by forcing incompletions, making sure tackles and not allowing Arizona to get into a rhythm. They’ll surely try it again Sunday, and how San Francisco adjusts to it may be the biggest key of the game.