Kansas City Chiefs at Indianapolis Colts odds, picks and predictions

The Kansas City Chiefs (2-0) take on the Indianapolis Colts (0-1-1) Sunday at Lucas Oil Stadium for a 1 p.m. ET kickoff (CBS). Below, we analyze Tipico Sportsbook‘s lines around the Chiefs vs. Colts odds, and make our expert NFL picks and predictions.

The undefeated Chiefs are coming off a 27-24 Thursday night win over the AFC West rival Los Angeles Chargers. QB Patrick Mahomes has led the way to K.C.’s 2 victories by throwing for 595 yards and 7 TD while not yet throwing an INT. The Chiefs’ offense is tied for 2nd with the Detroit Lions in points per game with 35.5, just behind the Buffalo Bills (36 PPG).

The winless Colts scored 0 points against the Jacksonville Jaguars in Week 2. QB Matt Ryan has thrown 4 INT this season (tied for 2nd most in the league), although he was without WRs Michael Pittman and Alec Pierce last week due to injuries.

Indy won its last matchup against the Chiefs in 2019 and leads the overall series 17-10. Ryan is 0-2 against the Andy Reid-coached Chiefs in his career.

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Chiefs at Colts odds

Provided by Tipico Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated Saturday at 9 a.m. ET.

Money line (ML): Chiefs -240 (bet $240 to win $100) | Colts +200 (bet $100 to win $200)
Against the spread (ATS): Chiefs -5.5 (-115) | Colts +5.5 (-105)
Over/Under (O/U): 50.5 (O: -115 | U: -105)

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Chiefs at Colts key injuries

Chiefs

K Harrison Butker (ankle) out
DE Mike Danna (calf) out

Colts

LB Shaquille Leonard (back) out
DE Yannick Ngakoue (back) questionable

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Chiefs at Colts picks and predictions

Prediction

Chiefs 41, Colts 20

Money line

This should be a win for the Chiefs who have beaten much tougher competition this season. It’ll be near impossible for the Colts, who have averaged 10 points per game (worst in the NFL), to keep up with one of the league’s top offenses. Equipped with that knowledge, you should include the CHIEFS (-240) into any NFL parlay that you plan to play in Week 3.

Against the spread

Again, CHIEFS -5.5 (-115) is a no-brainer. Winning by more than a TD is more than doable for a team that is tied for the second-most TDs (9) in the league.

Over/Under

The Over/Under is tricky for this game because it depends on defense as well, not just offense. We know the Chiefs will put up points, but how much will they allow? Recent play suggests the Colts won’t score much, but they’re returning Pittman from injury and the Chiefs are missing one of their top run-stoppers in LB Willie Gay due to suspension. That means the Colts could hypothetically score more points than previous weeks, even if it comes during garbage time.

I would AVOID the Over/Under for this matchup and stick to the spread and money line.

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