Kansas City Chiefs at Carolina Panthers odds, picks and predictions

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The Kansas City Chiefs (9-1) meet the Carolina Panthers (3-7) in a Week 12 matchup Sunday at Bank of America Stadium in Charlotte. Kickoff is scheduled for 1 p.m. ET (CBS). Let’s analyze BetMGM Sportsbook’s NFL odds around the Chiefs vs. Panthers odds, and make our expert NFL picks and predictions.

The Chiefs are likely angry after suffering their first loss of the season in Buffalo last week 30-21 against the Bills. Kansas City failed to cover for the fourth consecutive game last week, too, and it is 1-2-1 against the spread (ATS) in the past 4 road contests. The Over has cashed in 3 of the past 4 outings.

The Panthers have picked up outright wins in the past 2 games against the New Orleans Saints in Charlotte, and against the New York Giants in Munich, Germany. Carolina is coming off a bye week. The Over has cashed in 6 of the past 8 outings for the Panthers.

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Chiefs at Panthers odds

Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list of NFL odds. Lines last updated at 12:08 a.m. ET.

Moneyline (ML): Chiefs -700 (bet $700 to win $100) | Panthers +500 (bet $100 to win $500)
Against the spread (ATS): Chiefs -11 (-110) | Panthers +11 (-110)
Over/Under (O/U): 43 (O: -110 | U: -110)

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Chiefs at Panthers key injuries

Chiefs

No notable injuries

Panthers

DE Jadeveon Clowney (knee) questionable
WR Jalen Coker (quadriceps) questionable
PK Eddy Pineiro (knee) questionable
RB Miles Sanders (ankle) out
WR Adam Thielen (hamstring) questionable

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Chiefs at Panthers picks and predictions

Prediction

Chiefs 32, Panthers 16

Moneyline

The Chiefs (-700) will cost you 7 times your potential return, which is way too expensive. Even as part of a multi-leg parlay, including Kansas City would suck all of the value out of your ticket.

AVOID.

Against the spread

Backing a double-digit favorite on the road is always risky business, but the CHIEFS -11 (-110) are worth a look. This is a team which suffered its first loss last week in Buffalo, and it will head to Charlotte with anger and attitude.

The Panthers +11 (-110) are coming off a bye, but they’re the team with several injuries, while the Chiefs head into this game with no key players on the injury report.

Over/Under

OVER 43 (-110) is a good play in this AFC vs. NFC battle in the Queen City.

Carolina’s defense has really struggled this season, particularly against the rush. Kansas City should do most of the heavy lifting to cash the Over.

The Panthers have cashed high in 6 of the past 8 games, with Carolina allowing 22 or more points in 9 of 10 games this season. The Over has cashed in Carolina’s past 3 tries against AFC teams, too.

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