Jacksonville Jaguars at Kansas City Chiefs odds, picks and predictions

Analyzing Sunday’s Jacksonville Jaguars at Kansas City Chiefs odds and lines, with expert NFL picks, predictions and best bets.

The Jacksonville Jaguars (3-6) and Kansas City Chiefs (6-2) face off Sunday in a Week 10 matchup. Kickoff at Arrowhead Stadium will be at 1 p.m. ET (CBS). Below, we analyze Tipico Sportsbook‘s lines around the Jaguars vs. Chiefs odds, and make our expert NFL picks and predictions.

The Jaguars are coming off a 27-20 come-from-behind victory against the Las Vegas Raiders in Week 9 after being down 17-0 in the 2nd quarter. Jaguars RB Travis Etienne picked up 109 yards rushing and 2 TDs on 28 carries in the win.

The Chiefs won a 20-17 overtime thriller against the Tennessee Titans last Sunday night. QB Patrick Mahomes threw a personal record 68 passes in the game, throwing for 1 TD and 1 INT. Mahomes also picked up 63 yards and 1 TD on 6 carries.

The Chiefs are 2-0 against Jacksonville with Mahomes at QB, winning by a combined 70-40 score. However, the Jaguars had a different coach and QB in those games. The Chiefs have never faced Jaguars QB Trevor Lawrence, though Kansas City is 1-0 against Doug Pederson when he was coach for the Philadelphia Eagles in 2017. Pederson is a former protégé of Chiefs coach Andy Reid — he came up under Reid as an assistant in Philly and later as an offensive coordinator in Kansas City.

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Jaguars at Chiefs odds

Provided by Tipico Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated at 12:12 a.m. ET.

  • Moneyline (ML): Jaguars +325 (bet $100 to win $325) | Chiefs -400 (bet $400 to win $100)
  • Against the spread (ATS): Jaguars +9 (-111) | Chiefs -9 (-109)
  • Over/Under (O/U): 51.5 (O: -111 | U: -109)

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Jaguars at Chiefs key injuries

Jaguars

  • S Rayshawn Jenkins (concussion) questionable

Chiefs

  • WR Mecole Hardman (abdomen) out
  • RB Jerick McKinnon (shoulder/knee/hamstring) questionable

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Jaguars at Chiefs picks and predictions

Prediction

Chiefs 31, Jaguars 17

Moneyline

The Chiefs boast the league’s best offense and the Jaguars have the 11th-worst pass defense. A win for Kansas City, a top-3 team at the very least, seems like a no-brainer. Hence why the Chiefs are huge favorites at -400, which is definitely not a good enough payout to worth consideration.

AVOID the moneyline.

Against the spread

Neither squad has been great against the spread this season — the Chiefs are 3-5 ATS and the Jags are 3-6. The Chiefs don’t cover the spread often when they’re heavily favored, but an exception should be made against Jags who have lost ATS in 5 of their last 6 games.

Lean CHIEFS -9 (-109).

Over/Under

The Chiefs offense hasn’t fared well against the AFC South this season, and the Jaguars offense is putting up around 22 points per game. Lawrence also has 2 INTs and 2 fumbles in his last 2 games. Don’t expect a lot of scoring in this game compared to other Chiefs games.

Bet UNDER 51.5 (-109).

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