Iowa State Cyclones at Oklahoma Sooners odds, picks and predictions

Analyzing Saturday’s Iowa State at Oklahoma odds and lines, with college football expert picks, predictions and best bets.

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The Iowa State Cyclones (2-2, 1-0 Big 12) are on the road to face the No. 14 Oklahoma Sooners (4-0, 1-0) Saturday night. Kickoff from Gaylord Family-Oklahoma Memorial Stadium in Norman is 7 p.m. ET (FS1). Below, we analyze BetMGM Sportsbook’s lines around the Iowa State vs. Oklahoma odds, and make our expert college football picks and predictions.

Iowa State snapped a 2-game skid with a 34-27 home win over Oklahoma State last week to kick off Big 12 Conference play, covering the 3.5-point spread as favorites. The Over (36.5) hit in the win.

Oklahoma is No. 14 in the US LBM Coaches Poll powered by USA TODAY Sports. They kicked off conference play last week with a 20-6 road win over Cincinnati, covering the 13.5-point spread as favorites as the Under (57) cashed. They have won all 4 of their games this season by at least 14 points.

Rankings: US LBM Coaches Poll powered by USA TODAY Sports

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Iowa State at Oklahoma odds

Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated Friday at 6:18 p.m. ET.

  • Moneyline (ML): Iowa State +775 (bet $100 to win $775) | Oklahoma -1400 (bet $1,400 to win $100)
  • Against the spread (ATS): Iowa State +20 (-110) | Oklahoma -20 (-110)
  • Over/Under (O/U): 48.5 (O: -110 | U: -110)

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Iowa State at Oklahoma picks and predictions

Prediction

Oklahoma 34, Iowa State 13

Moneyline

Oklahoma has rolled to 4 straight wins by at least 14 points. The Sooners have beaten the Cyclones in 3 straight and in 8 of the last 10 matchups. But with a -1400 line, it isn’t worth any action.

PASS and look to the spread.

Against the spread

Oklahoma has covered the spread in all 4 games this season while Iowa State has failed to cover the spread in either of its losses.

Oklahoma’s 20 points were a season-low last week, but the Sooners have averaged 46.8 points per game. No opponent has scored more than 17 points.

Iowa State has a combined 20 points in their 2 losses.

BET OKLAHOMA -20 (-110).

Over/Under

After 3 straight games without reaching a 40-point total, Iowa State’s win over Oklahoma State had 61 points, blowing past the 36.5-point projected total.

Two of Oklahoma’s games have not reached 40 points. It will be close, but Oklahoma will not reach 40 this week and Iowa State will struggle to score against the Sooners.

BET UNDER 48.5 (-110).

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