Indiana at Ohio State odds, picks and predictions

Analyzing Saturday’s Indiana at Ohio State odds and lines, with college football expert picks, predictions and best bets.

The Indiana Hoosiers (3-6, 1-5 Big Ten) meet the No. 2 Ohio State Buckeyes (9-0, 6-0) Saturday at Ohio Stadium. Kickoff is scheduled for noon ET (FOX). Below, we analyze Tipico Sportsbook‘s lines around the Indiana vs. Ohio State odds, and make our expert college football picks and predictions.

Rankings courtesy of the AFCA Coaches Poll powered by USA TODAY Sports.

The Hoosiers are tied for last in the East Division with just 1 conference victory in 6 tries. Since topping Illinois in the regular-season opener Sept. 2, Indiana has dropped 6 straight Big Ten games by 5 or more points, with 4 of the setbacks coming by 14 or more points.

The Buckeyes won just 21-7 in a road trip to Northwestern, struggling with gusty winds to gale force in Evanston and failing to cover a 37.5-point spread. That ended a 7-game streak with at least 44 points, but the 7 points allowed was also a season-best.

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Indiana at Ohio State odds

Provided by Tipico Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated Thursday at 7 a.m. ET.

  • Moneyline (ML): Off the board (OTB)
  • Against the spread: Indiana +40.5 (-112) | Ohio State -40.5 (-108)
  • Over/Under (O/U): 57.5 (O: -117 | U: -103)

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Indiana at Ohio State picks and predictions

Prediction

Ohio State 55, Indiana 14

Moneyline

There was no money line at the time of publishing, but it wouldn’t be worth pursuing even if one is released before kickoff.

Against the spread

OHIO STATE -40.5 (-108) is the slight lean here, but play this very lightly.

If we learned anything last week, it’s that the fall weather is just as much a factor as the offenses and defenses playing the game.

The temperature will be around 40 degrees with winds anywhere from 9-12 mph, but it won’t be nearly as blustery as last weekend at Northwestern. The high-octane pass game for Ohio State should be effective yet again with more favorable conditions.

Over/Under

OVER 57.5 (-117) is the best play on the board.

Ohio State is certain to be angry after last week’s struggles against a 1-win Northwestern side. While the weather certainly was to blame, the Buckeyes made national headlines due to the poor performance, although ultimately Ohio State won, and it didn’t affect its standing in the College Football Playoff rankings.

Still, it wouldn’t be surprising to see Ohio State take care of the Over all on its own here.

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