The Denver Broncos (1-1) will host the San Francisco 49ers (1-1) on Sunday Night Football in Week 3 of the 2022 NFL season on Sunday, Sept. 25 at 6:20 p.m. MT.
The prime-time showdown will be nationally televised on NBC and fans can stream the game on fuboTV (try it free).
Mike Tirico (play-by-play) and Cris Collinsworth (analyst) will call the game for NBC with Melissa Stark reporting from the sideline.
On the radio, the game will air locally on KOA 850 AM/94.1 FM, and nationally on Westwood One.
The Broncos are coming off an underwhelming 16-9 win over the Houston Texans while the 49ers are coming off a convincing 27-7 win over the Seattle Seahawks in Week 2.
Despite playing at home, Denver is considered a 1.5-point underdog against San Francisco, according to Tipico Sportsbook.
The Broncos own a 7-8 all-time record against the 49ers, with their most notable meeting being a 55-10 San Francisco win in Super Bowl XXIV. The 49ers also won their most recent meeting 20-14 in 2018 at home.
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