Houston Texans at Indianapolis Colts odds, picks and predictions

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The Houston Texans and Indianapolis Colts meet Sunday in an AFC South battle as both teams kick off their 2024 seasons. Kickoff from Lucas Oil Stadium is set for 1 p.m. ET (CBS). Below, we analyze BetMGM Sportsbook’s lines around the Texans vs. Colts odds, and make our expert NFL picks and predictions.

Houston added a lot of key pieces this offseason with the hopes of building on what was a successful 2023 campaign that ended with a 34-10 loss vs. Baltimore in the Divisional Round of the playoffs. WR Stefon Diggs, RB Joe Mixon and DE Danielle Hunter were among the key additions for the Texans.

Indianapolis is looking to see if QB Anthony Richardson can improve on a rookie year that involved shoulder surgery, but also some signs of potential, this season. The Colts acquired some big names in the draft with UCLA DE Laiatu Latu and Texas WR Adonai Mitchell, who they hope will both contribute as rookies.

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Texans at Colts odds

Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated Saturday at 12:20 p.m. ET.

Moneyline (ML): Texans -160 (bet $160 to win $100) | Colts +130 (bet $100 to win $130)
Against the spread (ATS): Texans -3 (-105) | Colts +3 (-115)
Over/Under (O/U):49 (O: -110 | U: -110)

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Texans at Colts key injuries

Texans

None

Colts

WR Josh Downs (ankle) out

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Texans at Colts picks and predictions

Prediction

Texans 27, Colts 24

Moneyline

BET TEXANS (-160).

I like the Texans to win here as they are the more talented and more proven team. We saw last year what C.J. Stroud can do, and going into this game he has even more weapons at his disposal, and another year of camp and preseason should give him even more comfort.

Against the spread

LEAN COLTS +3 (-115).

This is a divisional game, and we know that divisional games are often the toughest, and closest games we see in the regular season. Combine that with the fact that Houston has a lot of new pieces to integrate on both sides of the ball, and you will see that Indianapolis will have chances in this game. I expect for the Colts to keep this one close.

This is a lean because Houston is the better team, and while Richardson did show flashes of potential, his accuracy throwing the ball is still questionable.

Over/Under

BET OVER 49 (-110).

The Texans should have a very potent offense that will tear up this lackluster Colts defense. Houston’s defense got better in the offseason, but there are a lot of pieces that are new and, like with the offense, we will likely see some growing pains that Indy should be able to take advantage of to score some points.

Be aware that this line comes with risk as Houston’s defense will likely be improved.

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For more sports betting picks and tips, check out SportsbookWire.com and BetFTW.

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