Houston Astros at Los Angeles Angels odds, picks and predictions

Analyzing Wednesday’s Houston Astros vs. Los Angeles Angels odds and lines, with MLB expert picks and predictions.

The Houston Astros (57-29) and Los Angeles Angels (38-50) play the second contest of a 3-game set Wednesday at Angel Stadium. First pitch is scheduled for 9:38 p.m. ET. Let’s analyze Tipico Sportsbook‘s lines around the Astros vs. Angels odds with MLB picks and predictions.

Season series: Astros lead series 8-3

The Astros picked up the narrow 6-5 victory in the series opener Tuesday, as Houston continues to dominate the season series against its AL West rivals.

The Angels are in a tailspin, going just 1-5 in their last 7 against divisional opponents, while going just 6-16 in the previous 22 games at home.

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Astros at Angels projected starters

RHP Cristian Javier vs. RHP Shohei Ohtani

Javier (6-4, 3.01 ERA) makes his 13th start and 17th overall appearance. He has a 0.99 WHIP, 3.3 BB/9 and 12.3 K/9 through 74 2/3 IP.

  • Is 2-1 with a 3.56 ERA with a .207 opponent batting average with 41 K in 30 1/3 IP across 5 starts and 2 bullpen appearances on the road.
  • Has managed a 1-0 record, 0.73 ERA and .146 OBA with 21 K in 12 1/3 IP across 1 start and 2 relief appearances vs. LAA in 2022.

Ohtani (8-4, 2.44 ERA) makes his 15th start. He has a 0.99 WHIP, 2.2 BB/9 and 12.3 K/9 through 81 IP.

  • Has posted a 4-2 record, 2.13 ERA and .184 OBA with 58 K across 42 1/3 IP in 7 home starts.
  • Is 1-1 with a 0.84 ERA and .135 OBA with 21 K across 10 2/3 IP in 2 starts vs. HOU this season.

Astros at Angels odds and lines

Odds provided by Tipico Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated at 6:30 a.m. ET.

  • Money line (ML): Astros +105 (bet $100 to win $105) | Angels -130 (bet $130 to win $100)
  • Run line (RL)/Against the spread (ATS): Astros +1.5 (-210) | Angels -1.5 (+170)
  • Over/Under (O/U): 7.5 (O: +100 | U: -125)

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Astros at Angels picks and predictions

Prediction

Angels 3, Astros 2

Money line

The ANGELS (-130) are a decent play behind the two-way star Ohtani, especially working at home.

The Halos are a bit of a risky play considering the fact they’re 1-6 in the past seven games against AL West opponents. However, it’s all about Ohtani when he is on the bump. The Angels have struggled overall, but they have won 5 straight starts when Ohtani toes the slab.

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Run line/Against the spread

The Astros +1.5 (-210) will cost you more than 2 times your potential return, and that’s expensive if you want some insurance. Just play Houston straight up if you like them, although I certainly do not with Ohtani on the bump.

AVOID.

Over/Under

The UNDER 7.5 (-125) is a strong play with Javier and Ohtani on the hill. Both of these pitchers put up a lot of donuts.

We saw the Over hit in Tuesday’s game, as the Angels blew a 4-run lead in the bottom of the 7th inning. Runs will be at more of a premium in this one.

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