The USC Trojans (1-0) and Stanford Cardinal (1-0) meet Saturday at Stanford Stadium in Stanford, Calif. Kickoff is set for 7:30 p.m. ET (ABC). Below, we analyze Tipico Sportsbook‘s lines around the USC vs. Stanford odds; check back for our college football picks and predictions.
USC cooked Rice 66-14 Saturday in a game that saw the Trojans score a whopping 52 points over the middle 2 quarters. Southern California scored on every one of its possessions in the first 3 quarters of play.
The Trojans’ defense got in on the act with a trio of pick-6s on their way to their most points in a single game since winning at Washington State 69-0 in 2008.
Stanford defeated FCS Colgate 41-0 Saturday. QB Tanner McKee threw for 308 yards, his 2nd-highest output in 12 career games. The Cardinal won handily despite being a minus-3 in turnovers.
Southern Cal was No. 15 in the initial AFCA Coaches Poll powered by USA TODAY Sports.
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USC at Stanford odds, spread and lines
Odds provided by Tipico Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated Monday at 10:07 a.m. ET.
- Money line: USC -320 (bet $320 to win $100) | Stanford +250 (bet $100 to win $250)
- Against the spread (ATS): USC -8.5 (-112) | Stanford +8.5 (-108)
- Over/Under (O/U): 64.5 (O: -117 | U: -103)
2022 betting stats:
- ML: USC 1-0 | Stanford 1-0
- ATS: USC 1-0 | Stanford 0-1
- O/U: USC 1-0 | Stanford 0-1
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USC vs. Stanford head-to-head
Saturday’s battle will mark the 100th meeting between USC and Stanford. The Trojans lead the series 62-34-3. Stanford won last year’s meeting 42-28, and the Cardinal are 2-1 vs. Southern Cal since 2018. Stanford is 4-1 over its last 5 home games against USC.
The Cardinal are 6-2 ATS in the last 8 series meetings. The Over is 4-1 across the last 5.
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