First look: USC at Arizona odds and lines

Looking at Saturday’s USC at Arizona college football odds, lines and trends. Here’s what you need to know.

The No. 11 USC Trojans (6-1, 4-1 Pac-12) will face the Arizona Wildcats (3-4, 1-3) Saturday at Arizona Stadium. Kickoff is scheduled for 7 p.m. ET (Pac-12 Network). Below, we look at USC vs. Arizona school odds from Tipico Sportsbook; check back for all our college football picks and predictions.

The Trojans are coming off a bye week following their first loss of the season to Utah by the score of 43-42. Despite no longer being unbeaten, USC still boasts 1 of the most exciting quarterbacks in college football in QB Caleb Williams.

The Wildcats are also coming off a bye week following a loss as they’ve lost 3 out of their last 4 games, which were all conference games. Arizona will lean on QB Jayden De Laura to air it out on USC’s defense as he has thrown for 2,274 yards, 19 touchdowns and 7 interceptions this season.

USC will enter Saturday’s Pac-12 showdown as the No. 11 ranked team in the AFCA Coaches Poll powered by USA TODAY Sports.

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USC at Arizona odds

Provided by Tipico Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated Monday at 2:10 p.m. ET.

  • Moneyline (ML): Off the board (OTB)
  • Against the spread (ATS): USC -14.5 (-115) | Arizona +14.5 (-107)
  • Over/Under (O/U): 75.5 (O: -112 | U: -108)

2022 betting stats

  • ML: USC 6-1 | Arizona 3-4
  • ATS: USC 5-2 | Arizona 4-3
  • O/U: USC 4-3 | Arizona 5-2

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USC vs. Arizona head-to-head

The Trojans and the Wildcats will square off against each other for the 45th time on Saturday. USC has a massive advantage over Arizona with a 36-8 record in the first 44 meetings.

The Trojans are amid a 9-game winning streak over the Wildcats dating back to 2013. Arizona’s last win over USC came in Oct. 2012 when the Wildcats escaped with a 39-36 win at home.

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