First look: Tennessee Titans at Indianapolis Colts odds and lines

Looking at Sunday’s Tennessee Titans at Indianapolis Colts Week 4 NFL odds, lines and trends. Here’s what you need to know.

The Tennessee Titans (1-2) hit the road in Week 4 for an AFC South divisional game against the Indianapolis Colts (1-1-1) in an early Sunday game. Kickoff is 1 p.m. ET at Lucas Oil Stadium (FOX). Below, we look at Titans vs. Colts odds from Tipico Sportsbook; check back for all our NFL picks and predictions.

Also seeAll Week 4 odds and lines

The Titans got their first win of the season on Sunday, a 24-22 victory over the Las Vegas Raiders. They scored all 24 points in the first half and held on to the end. They held the Raiders to 1-for-12 on 3rd down.

The Colts bounced back from a 24-0 shutout loss to the Jacksonville Jaguars with a 20-17 last-minute win over the Kansas City Chiefs. QB Matt Ryan threw a touchdown pass with 24 seconds remaining in the game to take the lead.

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Titans at Colts odds

Provided by Tipico Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated Monday at 1:45 p.m. ET.

  • Money line (ML): Titans +150 (bet $100 to win $150) | Colts -175 (bet $175 to win $100)
  • Against the spread (ATS): Titans +3.5 (-117) | Colts -3.5 (-103)
  • Over/Under (O/U): 42.5 (O: -117 | U: -103)

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2022 betting stats

  • ML: Titans 1-2 | Colts 1-1-1
  • ATS: Titans 1-2 | Colts 1-2
  • O/U: Titans 2-1 | Colts 0-3

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Titans vs. Cots head-to-head

The Titans and Colts have faced each other 54 times in the regular season and once in the playoffs. The Colts lead the all-time series 35-20.

But the Titans have won the last 3 matchups and 4 of the last 5. They swept the season series a year ago with a 25-16 win in Nashville and a 35-31 overtime win in Indy.

Titans QB Ryan Tannehill is 5-4 in 9 career starts against the Colts.

This is QB Matt Ryan’s first game against the Titans as a member of the Colts. While he played for Atlanta, he went 2-1 in 3 career starts against the Titans.

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