First look: Seattle Seahawks at Arizona Cardinals odds and lines

Looking at Sunday’s Seattle Seahawks at Arizona Cardinals Week 18 NFL odds, lines and trends. Here’s what you need to know.

The Seattle Seahawks (6-10) and Arizona Cardinals (11-5) tangle in a Week 18 contest Sunday. The game at State Farm Stadium is slated for a 4:25 p.m. ET kickoff. Below, we look at the Seahawks vs. Cardinals odds and lines; check back for our NFL picks and predictions.

Seattle clocked a 51-29 victory over the visiting Detroit Lions Sunday. QB Russell Wilson threw 4 touchdowns and RB Rashaad Penny rambled for 170 yards and 2 scores. The Seahawks benefited from three Detroit turnovers while going 8-for-13 on third and fourth downs. The Seahawks’ 51 points Sunday were the franchise’s most in a single game since Week 14 in 2012 against … the Arizona Cardinals (58 points).

The Cardinals snapped a three-game skid with a 25-22 win at Dallas. Arizona held on after PK Matt Prater’s field goal gave the Cardinals a 22-7 lead with 4:01 remaining in the third quarter. The Cards now return home where they have lost their last four games and haven’t won since Oct. 24.

Also see: All Week 18 odds and lines

Seahawks at Cardinals odds, spread and lines

Odds provided by Tipico Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated Monday at 4:04 p.m. ET.

  • Money line: Seahawks +220 (bet $100 to win $220) | Cardinals -280 (bet $280 to win $100)
  • Against the spread (ATS): Seahawks +6.5, -110 (bet $110 to win $100) | Cardinals -6.5, -110 (bet $110 to win $100)
  • Over/Under (O/U): 47.5, O: -115 (bet $115 to win $100) | U: -105 (bet $105 to win $100)

Also see: Betting 101

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2021 betting stats:

  • ML: Seahawks 6-10 | Cardinals 11-5
  • ATS: Seahawks 8-8 | Cardinals 10-6
  • O/U: Seahawks 5-11 | Cardinals 7-9

Seahawks at Cardinals head-to-head

Arizona beat Seattle 23-13 in Week 11 (Nov. 21). The Cardinals held the Seahawks 2-for-10 on third-down attempts, and Seattle managed just 266 total yards.

The Cards are 3-1 across their last four games against the Seahawks. The all-time Seattle-Arizona series is tied 22-22-1. Against the number, the underdog is 10-2-1 in the last 13 meetings.

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