The Kansas City Chiefs (2-0) get back on the road to face the Indianapolis Colts (0-1-1) Sunday at Lucas Oil Stadium for a 1 p.m. ET kickoff (CBS). Below, we look at Chiefs vs. Colts odds from Tipico Sportsbook; check back for all our NFL picks and predictions.
The Chiefs are coming off a nail-biting divisional win Thursday night when they held off the Los Angeles Chargers 27-24. Chiefs QB Patrick Mahomes threw for 235 yards with 2 TDs, while RB Clyde Edwards-Helaire racked up 118 total yards (74 rushing, 44 receiving) on 12 touches. It was rookie CB Jaylen Watson who earned the biggest highlight of the night, nabbing a 99-yard INT return for a TD that gave K.C. the lead in the 4th quarter.
The Colts followed up their Week 1 tie with a rough outing that saw them put up no points. Indy lost to the Jacksonville 24-0 while Colts QB Matt Ryan (16-for-30 pass attempts for 195 yards with 0 touchdowns) struggled to get any momentum going, likely due to missing WRs Michael Pittman Jr. and Alec Pierce to injury. Ryan threw 3 INTs and star RB Jonathan Taylor was held to just 54 rushing yards on 9 carries.
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Chiefs at Colts odds
Provided by Tipico Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated Monday at 4:38 p.m. ET.
- Money line (ML): Chiefs -280 (bet $280 to win $100) | Colts +230 (bet $100 to win $230)
- Against the spread (ATS): Chiefs -6.5 (-115) | Colts +6.5 (-105)
- Over/Under (O/U): 49.5 (O: -110 | U: -110)
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2022 betting stats
- ML: Chiefs 2-0 | Colts 0-1-1
- ATS: Chiefs 1-1 | Colts 0-2
- O/U: Chiefs 1-1 | Colts 0-2
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Chiefs vs. Colts head-to-head
This is the first matchup between the Chiefs and Colts since October 2019 in which the Colts won 19-13 in Kansas City. The Colts lead the overall series 17-10, including 4-1 in the postseason.
This is also Ryan’s first game against the Chiefs since 2020, when he lost 17-14 as QB for the Atlanta Falcons. Ryan threw for 300 yards and 2 TDs that day.
K.C. is 6-4 ATS in its last 10 games with an O/U of 8-2. The Chiefs were just 2 points Under the 53-point total against the Chargers in Week 2, while going 11 points Over in Week 1.
Indy is 4-6 ATS in its last 10 with an O/U of 2-8. The Colts were well Under the 44-point total as they were shut out by the Jaguars in Week 2. It was the Colts’ 7th consecutive Under, dating back to their final 5 games of last season.
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