First look: Indianapolis Colts at Jacksonville Jaguars odds and lines

Looking at Sunday’s Indianapolis Colts at Jacksonville Jaguars Week 5 NFL odds, lines and trends. Here’s what you need to know.

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The Indianapolis Colts (2-2) visit the Jacksonville Jaguars (0-4) in a Week 5 AFC South contest Sunday. The opening kickoff at EverBank Stadium will be at 1 p.m. ET (CBS) Let’s analyze BetMGM Sportsbook’s NFL odds around the Colts vs. Jaguars odds, and make our expert NFL picks and predictions.

Indianapolis grabbed a big early lead and then hung on for a 27-24 win over the Pittsburgh Steelers Sunday. The Colts were outgained, but leveraged the win — their 2nd in a row — on a plus-2 in turnovers and 8-of-15 performance in converting 3rd downs.

Jacksonville remained winless with a 24-20 loss to the Houston Texans Sunday. Host Houston scored the go-ahead TD with 18 seconds remaining in the 4th quarter. The Jaguars were outgained 445 yards to 313 in losing for the 9th time in their last 10 games.

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Colts at Jaguars odds

Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list of NFL odds. Lines last updated Monday at 12:38 a.m. ET.

  • Moneyline: Colts +120 (bet $100 to win $120) | Jaguars -145 (bet $145 to win $100)
  • Against the spread (ATS): Colts +2.5 (+100) | Jaguars -2.5 (-120)
  • Over/Under (O/U): 46.5 (O: -110 | U: -110)

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2024 betting stats

  • ML: Colts 2-2 | Jaguars 0-4
  • ATS: Colts 3-1 | Jaguars 2-2
  • O/U: Colts 2-2 | Jaguars 1-3

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Colts vs. Jaguars head-to-head

The last 5 series meetings have seen Jacksonville go 4-1, but Indianapolis leads the all-time series 27-19 since the 2 sides 1st met in 1995.

In Jacksonville, the Jags have won 9 in a row; 6 of those have been by multiple scores (9 points or more).

Since 2019, the Jaguars are 8-2 straight up and 6-4 ATS. The Over has cashed in 3 straight meetings and is 6-4 across those last 10 contests.

At home, Jacksonville is 9-0 SU and 9-0 ATS since 2015.

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