The Indianapolis Colts (5-5) are on the road for a meeting with the Buffalo Bills (6-3) Sunday in Week 11. Kickoff from Highmark Stadium is set for 1 p.m. ET. Below, we look at the Colts vs. Eagles odds and lines; check back for our NFL picks and predictions.
The Colts jumped out to a 17-0 lead in the first quarter and held on to topple the Jacksonville Jaguars 23-17 in Week 10. QB Carson Wentz was held to 180 yards and zero touchdowns or interceptions in the victory, while RB Jonathan Taylor punched in a touchdown for the seventh consecutive game and finished with 116 yards on 21 carries.
Also see: All Week 11 odds and lines
The Bills bounced back from a surprising Week 9 loss to the Jacksonville Jaguars by handling the division-rival New York Jets 45-17 in Week 10. QB Josh Allen was 21-for-28 passing for 366 yards and 2 touchdowns against 1 interception.
Four Bills rushed for touchdowns as running backs Devin Singletary (7 carries, 43 yards, 1 TD), Matt Breida (3 carries, 38 yards, 1 TD), Zack Moss (7 carries, 27 yards, 1 TD) and WR Isaiah McKenzie (2 carries, 17 yards, 1 TD) all found paydirt.
Colts at Bills odds, spread and lines
Odds provided by Tipico Sportsbook; access USA TODAY Sports’ betting odds for a full list. Lines last updated Monday at 7:50 a.m. ET.
- Money line: Colts +230 (bet $100 to win $230) | Bills -300 (bet $300 to win $100)
- Against the spread (ATS): Colts +6.5, -105 (bet $105 to win $100) | Bills -6.5, -115 (bet $115 to win $100)
- Over/Under (O/U): 49.5, O: -105 (bet $105 to win $100) | U: -115 (bet $115 to win $100)
Also see: Betting 101
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2021 betting stats:
- ML: Colts 5-5 | Bills 6-3
- ATS: Colts 6-4 | Bills 5-3-1
- O/U: Colts 6-4 | Bills 4-5
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Colts at Bills head-to-head
The Colts and Bills have met 71 times dating back to 1970 when the Indianapolis squad was based out of Baltimore. Buffalo leads the all-time series 38-32-1.
The Bills picked up a 27-24 victory at home last year in the AFC Wild Card Playoffs. Allen recorded his first playoff victory with 324 passing yards and 2 passing touchdowns while adding a score on the ground.
Buffalo is 4-3 SU/ATS across the last seven meetings while the Under has gone 5-2.
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