The Cleveland Browns and Carolina Panthers open the season against each other in Week 1 of the 2022 NFL season. Kickoff on Sunday,. Sept. 11, is at 1 p.m. ET (CBS) at Bank of America Stadium. Below, we analyze Tipico Sportsbook‘s lines around the Browns vs. Panthers odds and lines; check back for our NFL picks and predictions.
Both teams have new starting quarterbacks. The Browns traded for QB Deshaun Watson, but he was suspended for the first 11 games of the season under the league’s personal conduct policy, which means they turn to QB Jacoby Brissett. Cleveland missed the playoffs last season going 8-9.
A familiar face will lead the Panthers as the Browns traded former No. 1 overall pick Baker Mayfield to Carolina, where he was named the starting quarterback. The Panthers finished in last place in the NFC South last season at 5-12.
Also see: All Week 1 odds and lines
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Browns at Panthers odds, spread and lines
Odds provided by Tipico Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated Monday, Aug. 29, at 12:01 a.m. ET.
- Money line (ML): Browns +110 (bet $100 to win $110) | Panthers -135 (bet $135 to win $100)
- Against the spread (ATS): Browns +2.5 (-105) | Panthers -2.5 (-115)
- Over/Under (O/U): 41.5 (O: -108 | U: -112)
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2021 betting stats:
- ML: Browns 8-9 | Panthers 5-12
- ATS: Browns 7-10 | Panthers 5-12
- O/U: Browns 7-10 | Panthers 8-9
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Browns at Panthers head-to-head
The teams have only faced each other 6 times, the first time in 1999. The Panthers lead the all-time series 4-2, although the Browns have won 2 of the last 3 matchups.
The Browns won their last matchup in 2018, beating the Panthers 26-20.
The Panthers have won both games played in Carolina.
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