The No. 24 Clemson Tigers (4-2, 3-1 ACC) meet the No. 23 Pittsburgh Panthers (5-1, 2-0) at Heinz Field in Pittsburgh. Kickoff is scheduled for 3:30 p.m. ET. Below, we look at the Clemson vs. Pittsburgh odds and lines; check back for our college football picks and predictions.
The Tigers scratched out a 17-14 victory on the road in Syracuse, N.Y., but they didn’t come close to covering a 13.5-point number. Clemson has failed to cover in six tries this season, while the Under has cashed in five of the outings.
The Panthers were dominant for the second straight weekend on the road, topping Virginia Tech 28-7. Pitt has covered three in a row and five of six overall. The Under cashed against the Hokies, snapping a 5-0 Over run to start.
Rankings according to the AFCA Coaches Poll powered by USA TODAY Sports.
Clemson at Pittsburgh odds, spread and lines
Odds provided by Tipico Sportsbook; access USA TODAY Sports’ betting odds for a full list. Lines last updated Monday at 7:55 a.m. ET.
- Money line: Clemson +155 (bet $100 to win $155) | Pittsburgh -190 (bet $190 to win $100)
- Against the spread (ATS): Clemson +3.5, -112 (bet $112 to win $100) | Pittsburgh -3.5, -108 (bet $108 to win $100)
- Over/Under (O/U): 47.5, O: -105 (bet $105 to win $100) | U: -115 (bet $115 to win $100)
Also see: Betting 101
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2021 betting stats:
- ML: Clemson 4-2 | Pittsburgh 5-1
- ATS: Clemson 0-6 | Pittsburgh 5-1
- O/U: Clemson 1-5 | Pittsburgh 5-1
Clemson at Pittsburgh head-to-head
The all-time series is tied 2-2. Pitt won the first two meetings, including a 43-42 thriller in Clemson Nov. 12, 2016. The Tigers won the previous two meetings, including the 2018 ACC Championship Game, and a 52-17 rout at Clemson Nov. 28, 2020.
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