The Buffalo Bills (4-1) and Tennessee Titans (3-2) meet for Monday Night Football in Week 6. Kickoff from Nissan Stadium is set for 8:15 p.m. ET. Below, we look at the Bills vs. Titans odds and lines; check back for our NFL picks and predictions.
The Bills rattled off their fourth straight win with a 38-20 victory over the Kansas City Chiefs on Sunday Night Football in Week 5. The matchup was highly anticipated as a rematch of last year’s AFC Championship Game but largely was controlled throughout by the Bills as the Chiefs were unable to get within one score through the entire second half.
QB Josh Allen was 15-for-26 passing or 315 yards and 3 touchdowns, 2 of which were caught by WR Emmanuel Sanders. Allen also lead the Bills’ ground attack with 59 rushing yards on 11 carries.
The Titans kept the Jacksonville Jaguars winless with a 37-19 road victory in Week 5. WR A.J. Brown returned to action for the Titans but the receiving group was led by WR Marcus Johnson who finished with 52 yards on 3 catches from 5 targets.
Tennessee was led by RB Derrick Henry who recorded his fourth consecutive game with more than 110 yards. Henry scored 3 touchdowns in the victory with 130 yards on 29 carries.
Bills at Titans odds, spread and lines
Odds provided by Tipico Sportsbook; access USA TODAY Sports’ betting odds for a full list. Lines last updated Monday at 11:55 a.m. ET.
- Money line: Bills -210 (bet $210 to win $100) | Titans +170 (bet $100 to win $170)
- Against the spread (ATS): Bills -4.5, -110 (bet $110 to win $100) | Titans +4.5, -110 (bet $110 to win $100)
- Over/Under (O/U): 53.5, O: -115 (bet $115 to win $100) | U: -105 (bet $105 to win $100)
Also see: Betting 101
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2021 betting stats:
- ML: Bills 4-1 | Titans 3-2
- ATS: Bills 4-1 | Titans 3-2
- O/U: Bills 2-3 | Titans 3-2
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Bills at Titans head-to-head
Tennessee leads the all-time series with Buffalo 29-19, including a 42-16 victory in Week 5 last season. However, Allen is 2-1 against the Titans since joining Buffalo. The last six times the two clubs have squared off the underdog has covered the spread, dating back to 2011.
The Under has hit in three of the last four meetings.
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