First look: Buffalo Bills at Detroit Lions odds and lines

Looking at Sunday’s Buffalo Bills at Detroit Lions Week 15 NFL odds, lines and trends. Here’s what you need to know.

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The Buffalo Bills (10-3) take on the Detroit Lions (12-1) Sunday in Week 15. Kickoff from Ford Field is set for 4:25 p.m. ET (CBS). Below, we look at Bills vs. Lions odds from BetMGM Sportsbook’s NFL odds before making our expert NFL picks and predictions later in the week.

The Bills were unable to slow down the LA Rams in a 44-42 defeat in Week 14. They made a late charge, down 38-21 in the fourth quarter, but it wasn’t enough. QB Josh Allen firmly entrenched his name in the MVP race going 22-for-37 for 342 yards, 3 TDs and 0 INTs while rushing 10 times for 82 yards and 3 more TDs.

The Lions held off the Green Bay Packers Thursday night, 34-31, in their 11th straight victory. QB Jared Goff was 32-for-41 for 283 yards, 3 TDs and 1 INT. RB Jahmyr Gibbs had just 43 yards on 15 carries, but he caught 6 balls for 30 yards and a score.

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Bills at Lions odds

Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list of NFL odds. Lines last updated Monday at 9:36 a.m. ET.

  • Moneyline (ML): Bills +120 (bet $100 to win $120) | Lions -145 (bet $145 to win $100)
  • Against the spread (ATS): Bills +2.5 (+100) | Lions -2.5 (-120)
  • Over/Under (O/U): 53.5 (O: -110 | U: -110)

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2024 betting stats

  • ML: Bills 10-3 | Lions 12-1
  • ATS: Bills 8-5 | Lions 9-4
  • O/U: Bills 8-4-1 | Lions 6-6-1

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Bills vs. Lions head-to-head

The Bills lead the all-time series 7-4-1. The last meeting came in Detroit Nov. 24, 2022, and the Bills snuck away with a 28-25 victory. The Lions covered as 9-point dogs in a season they went 9-8. Allen threw for 253 yards, 2 TDs and 1 INT while rushing for 78 yards and a score. Goff went for 240 yards and 2 TDs — one of which was hauled in by WR Amon-Ra St. Brown. He had 9 receptions for 122 yards. The Under has cashed in 5 straight meetings dating back to 2006.

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