The Buffalo Bills (7-3) and Detroit Lions (4-6) open Thursday’s NFL Thanksgiving action with a 12:30 p.m. ET (CBS) contest at Ford Field. Below, we look at Bills vs. Lions odds from Tipico Sportsbook; check back for all our NFL picks and predictions.
Buffalo is playing in the Motor City for a 2nd-straight week. In a relocated contest due to blizzard conditions this past week in Buffalo, the favored-by-7.5 Bills defeated the Cleveland Browns 31-23 Sunday. The Buffalo defense held the Browns to 3.1 yards per carry; foes had rambled for 5.9 YPC over the Bills’ 3 previous games.
The Lions defeated the New York Giants 31-18, clocking their 3rd-straight win as an underdog. The favored-by-3 Giants outgained Detroit 413 yards to 325 but were undone by a minus-3 in the turnover category. The Lions’ win streak is the franchise’s longest singe 2017.
Also see: All Week 12 odds and lines
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Bills at Lions odds
Provided by Tipico Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated Monday at 7:50 a.m. ET.
- Moneyline: Bills -390 (bet $390 to win $100) | Lions +320 (bet $100 to win $320)
- Against the spread (ATS): Bills -8.5 (-110) | Lions +8.5 (-110)
- Over/Under (O/U): 52 (O: -112 | U: -108)
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2022 betting stats
- ML: Bills 7-3 | Lions 4-6
- ATS: Bills 5-4-1 | Lions 6-4
- O/U: Bills 3-7 | Lions 7-3
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Bills vs. Lions head-to-head
Buffalo and Detroit meet for the 1st time since 2018. The Bills won that game (Dec. 16, 2018) 14-13 and lead the all-time series 6-4-1.
Recent Buffalo-Detroit games have been of the low-scoring variety. The Under is 4-0 since 2006.
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