Detroit Lions at Minnesota Vikings odds, picks and predictions

The Detroit Lions (1-1) are on the road to face the NFC North rival Minnesota Vikings (1-1) Sunday. Kickoff at U.S. Bank Stadium is set for 1 p.m. ET (FOX). Below, we analyze Tipico Sportsbook‘s lines around the Lions vs. Vikings odds, and make our expert NFL picks and predictions.

After a dominating Week 1 win over the Green Bay Packers, the Vikings are looking to bounce back at home after a humbling 24-7 blowout loss at the Philadelphia Eagles on Monday Night Football.

The Lions are coming off a 36-27 win over the Washington Commanders and have been playing much better this season than the last couple of years. Detroit lost by 3 points to Philadelphia in Week 1 (38-35) after a strong late comeback that shaved a 17-point deficit down to just 3.

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Lions at Vikings odds

Provided by Tipico Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated Saturday at 9:45 a.m. ET.

Money line (ML): Lions +205 (bet $100 to win $205) | Vikings -250 (bet $250 to win $100)
Against the spread (ATS): Lions +6.5 (-117) | Vikings -6.5 (-103)
Over/Under (O/U): 52.5 (O: -108 | U: -112)

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Lions at Vikings key injuries

Lions

DL John Cominsky (wrist) out
TE T.J. Hockenson (hip) questionable
DL Aiden Hutchinson (thigh) questionable
OL Jonah Jackson (finger) out
C Frank Ragnow (foot) questionable
RB D’Andre Swift (ankle) questionable

Vikings

CB Andrew Booth Jr. (quad) out
LB Eric Kendricks (toe) questionable
S Harrison Smith (concussion) out

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Lions at Vikings picks and predictions

Prediction

Vikings 27, Lions 20

Money line

PASS.

If I was going to make a bet on this, it would likely be a very small value wager on the Lions because I don’t see the value of betting two and a half times your potential return on the Vikings.

Against the spread

TAKE THE VIKINGS -6.5 (-103)

Vikings QB Kirk Cousins is 7-1 as a Viking against the Lions and 4-0 at home. While last year’s home victory was close the 3 prior home victories included margins of 14, 13 and 15 points.

The Vikings were 5.5-point favorites earlier in the week, but it got bumped up to 6.5 after the final injury report was released. If Swift isn’t 100 percent and Lions coach Dan Campbell was cautious in his assessment Friday, the offense will suffer because he is a big-play machine.

I’m not 100 percent sold on laying 6.5 points with the Vikings, but they are a different team at home when the noise is deafening for the opposing offense.

Over/Under

TAKE THE UNDER 52.5 (-112).

The Vikings have won the last 4 home meetings with the Lions under Cousins, but RB Dalvin Cook has been the star. In his last three home games against the Lions, he has rushed 50 times for 357 yards and 3 touchdowns.

The result of Cook being effective on the ground is that it has slowed the game down and led to longer, time-consuming drives. Of the last 4 meetings at US Bank Stadium — all Minnesota wins — the point totals have been 36, 54, 27 and 33.

While both defenses are capable of getting burned, there should be enough field goals and not enough touchdowns to keep this one Under.

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