The Dallas Cowboys (0-1) visit the Arizona Cardinals (0-0) Friday for a 10 p.m. ET kickoff at State Farm Stadium. Below, we look at the Cowboys at Cardinals odds and lines, and make our best NFL picks, predictions and bets.
The Cowboys are coming off a Hall of Fame Game loss to the Pittsburgh Steelers in Canton, Ohio, and star QB Dak Prescott will miss another start after suffering a shoulder strain during the first week of training camp.
Backup QBs Garrett Gilbert and Ben DiNucci will get the bulk of the action in his place. Gilbert threw for 104 yards and was sacked twice last week.
The Cardinals will be without DL J.J. Watt, who has been rehabbing a hamstring injury. QB Kyler Murray will likely see one series of game action.
Cowboys at Cardinals odds, spread, and lines
Odds via Tipico Sportsbook; access USA TODAY Sports’ betting odds for a full list. Lines last updated at 4:30 p.m. ET.
- Money line: Cowboys +115 (bet $100 to win $115) | Cardinals -140 (bet $140 to win $100)
- Against the spread/ATS: Cowboys +2.5 (-105) | Cardinals -2.5, -115 (bet $115 to win $100)
- Total: 37.5 (O: -115 | U: -105)
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Cowboys at Cardinals odds, lines, predictions, and picks
Prediction
Cowboys 21, Cardinals 10
Money line
The Cardinals are slight favorites on the money line. Dallas reported to camp a week earlier and has an extra game under its belt, while Arizona will spend the bulk of the night working off the rust.
Take the COWBOYS (+115) as plus-money underdogs.
Against the spread
The Cowboys are 2.5-point underdogs on the road and even without Prescott, should cover with Gilbert perfectly capable of big-time passing performances.
Roll with the COWBOYS +2.5 (-105) with 2 points of insurance in the event of a loss.
Over/Under
Although both offenses are built for a shootout, Murray only playing one series should lead bettors to the UNDER 37.5 (-105).
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