The Indianapolis Colts (6-4) are underdogs when they travel to take on the Houston Texans (6-4) at NRG Stadium on Thursday night for a Week 12 matchup.
This matchup is huge for both teams. They are currently tied atop the AFC South with the Colts holding the tiebreaker due to their Week 7 win against the Texans at Lucas Oil Stadium.
It should be a physical game, but the experts are mostly siding with the Texans in Week 12:
| Expert | Pick | Score (if applicable) |
| Nate Davis (USA TODAY) | Texans | 28-24 |
| Mike Jones (USA TODAY) | Texans | 27-25 |
| Jarrett Bell (USA TODAY) | Texans | 24-21 |
| Mike Clay (ESPN) | Texans | N/A |
| Vinnie Iyer (Sporting News) | Texans | 24-20 |
| Pete Prisco (CBS Sports) | Texans | 28-21 |
| Jared Dubin (CBS Sports) | Texans | N/A |
| Todd Haislop (Sporting News) | Texans | 27-21 |
| NumberFire | Texans | N/A |
| Pro Football Focus | Texans | N/A |
| Bleacher Report | Texans | 24-21 |