The Indianapolis Colts (0-0) are set to visit the Houston Texans (0-0) at NRG Stadium as the 2022 NFL season officially gets underway.
As the Colts search for their first opening day win since 2013, they will have to make sure they win the big matchups. They might be the biggest favorites of the week in terms of the spread, but they still have to execute on the field.
Here are the biggest matchups to watch in the Week 1 bout between the Colts and Texans: