The Indianapolis Colts will commence the 2021 regular season with a home matchup against the Seattle Seahawks on Sunday at Lucas Oil Stadium.
Looking for their first season-opening win since 2013, the Colts have a tough challenge ahead of them. The spread on the game is still close, with Indy being 2.5-point home underdogs.
Here’s how the experts around the league are viewing this matchup:
| Expert | Pick | Score (if applicable) |
| Nate Davis (USA TODAY) | Seahawks | 27-23 |
| Mike Jones (USA TODAY) | Seahawks | 31-27 |
| Jarrett Bell (USA TODAY) | Seahawks | 28-24 |
| Mike Clay (ESPN) | Seahawks | N/A |
| Gregg Rosenthall (NFL Network) | Seahawks | 23-17 |
| Bill Bender (Sporting News) | Seahawks | 30-20 |
| Dave Richard (CBS Sports) | Seahawks | N/A |
| Pete Prisco (CBS Sports) | Colts | 24-23 |
| Mike Wells (ESPN) | Seahawks | 33-26 |
| Albert Breer (Sports Illustrated) | Colts | N/A |
| Bleacher Report | Colts | 27-26 |
As of this writing, 81% of the picks over at Tallysight are favoring the Seahawks. Given the issues the Colts have dealt with throughout the preseason when it comes to injuries, the safer bet seems to be the Seahawks.
The Colts are expected to have quarterback Carson Wentz (foot) starting the opener. He missed most of training camp and all of the preseason after undergoing foot surgery. They may also be without cornerback Xavier Rhodes, who hasn’t practiced entering Friday due to a calf injury.
This will certainly be a close matchup on Sunday, but the experts around the league are confident the opening-day losing streak for the Colts will continue.
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