The Indianapolis Colts (8-6) are set to visit the Arizona Cardinals (10-4) at State Farm Stadium on Saturday night for a Week 16 matchup in prime time.
The Christmas Day game will mark the second time in a row the Colts will play on a Saturday as they look to continue their streak as the hottest team in the AFC playoff race. With three games remaining, the Colts are 7-2 in their last nine games and currently lead the wild-card race.
Meanwhile, the Cardinals got off to a fast 7-0 start before going 3-4 in their last seven games. They still sit atop the NFC West and have the firepower to compete with any team in the NFL.
Here’s how the experts around the league see this matchup unfolding:
| Expert | Pick | Score (if applicable) |
| Nate Davis (USA TODAY) | Colts | 30-17 |
| Mike Jones (USA TODAY) | Colts | 28-25 |
| Jarrett Bell (USA TODAY) | Colts | 24-22 |
| Mike Clay (ESPN) | Cardinals | N/A |
| Gregg Rosenthall (NFL Network) | Colts | 24-23 |
| Vinnie Iyer (Sporting News) | Colts | 24-20 |
| Dave Richard (CBS Sports) | Colts | N/A |
| Pete Prisco (CBS Sports) | Cardinals | 30-20 |
| Jess Root (Cards Wire) | Cardinals | 31-28 |
| Cam DaSilva (Sportsbook Wire) | Colts | N/A |
| Bleacher Report | Cardinals | 24-23 |
Though this game is expected to be a close one, most of the experts side with the Colts taking the road game. Over at Tallysight, 59% of the analysts chose the Colts to win the game as of this writing.
It should be a tight contest considering the offensive firepower on each side. Even without center Ryan Kelly and right guard Mark Glowinski, the Colts have the offensive makeup to control the line of scrimmage and pound the rock against a Cardinals run defense that has been lacking for the majority of the season.
On the flip side, the Colts may struggle to keep Kyler Murray contained, which is likely going to be their biggest key in Week 16.
The Colts and Cardinals are set for kickoff at 8:15 p.m. ET on NFL Network.
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