The Indianapolis Colts (1-2-1) and Denver Broncos (2-2) are set to square off Thursday night at Empower Field for a prime-time matchup in Week 5.
As the Colts enter this short week underdogs on the road, the Colts Wire staff made their picks and predictions for the team’s first prime-time game of the season.
Here are the picks and predictions for the Week 5 game: