Game Information
Who: Indianapolis Colts (2-4) at San Francisco 49ers (2-3)
When: Sunday, Oct. 24, 8:20 p.m. ET
Where: Levi’s Stadium — Santa Clara, CA
How To Watch
Channel: NBC (national)
Broadcast: Al Michaels (play-by-play), Cris Collinsworth (color analyst), Michele Tafoya
How To Stream
fuboTV (try it free)
How To Listen
WFNI — Indianapolis, IN
WHLK — Indianapolis, IN
Sirius XM Radio (Colts) — Channel 85 (XM App 226)
Sirius XM Radio (49ers) — Channel 211 (XM App 225)
Injuries
Final injury report for both teams
Quenton Nelson activated from IR
T.Y. Hilton downgraded to OUT
Picks & Predictions
Colts Wire Staff Picks
Expert Picks
Colts are 4.5-point underdogs on the road
Opponent Site
2021 Schedule
| Week | Opponent | Date | Time (ET) | Network | Result |
| 1 | Seahawks | Sept. 12 | 1:00 p.m. | FOX | L, 28-16 |
| 2 | Rams | Sept. 19 | 1:00 p.m. | FOX | L, 27-24 |
| 3 | @ Titans | Sept. 26 | 1:00 p.m. | CBS | L, 25-16 |
| 4 | @ Dolphins | Oct. 3 | 1:00 p.m. | CBS | W, 27-17 |
| 5 | @ Ravens | Oct. 11 | 8:15 p.m. | ESPN | L, 31-25 (OT) |
| 6 | Texans | Oct. 17 | 1:00 p.m. | CBS | W, 31-3 |
| 7 | @ 49ers | Oct. 24 | 8:20 p.m. | NBC | |
| 8 | Titans | Oct. 31 | 1:00 p.m. | CBS | |
| 9 | Jets | Nov. 4 (TNF) | 8:20 p.m. | NFLN | |
| 10 | Jaguars | Nov. 14 | 1:00 p.m. | CBS | |
| 11 | @ Bills | Nov. 21 | 1:00 p.m. | CBS | |
| 12 | Buccaneers | Nov. 28 | 1:00 p.m. | FOX | |
| 13 | @ Texans | Dec. 5 | 1:00 p.m. | CBS | |
| 14 | BYE | BYE | BYE | ||
| 15 | Patriots | Dec. 18/19 | TBD | TBD | |
| 16 | @ Cardinals | Dec. 25 | 8:15 p.m. | NFLN | |
| 17 | Raiders | Jan. 2 | 1:00 p.m. | CBS | |
| 18 | @ Jaguars | Jan. 9 | 1:00 p.m. | CBS |
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