The Indianapolis Colts (9-7) will be entering the weekend as massive road favorites over the Jacksonville Jaguars (2-14) in Week 18.
The matchup will be the key to clinching a playoff berth for the Colts if they come out with a win. In the eyes of Vegas, the Colts are still 15.5-point favorites on the road, per Tipico Sportsbook.
| Spread | Moneyline | Total Points | |
| Indianapolis Colts (9-7) | -15.5 | -1400 | O 43.5 -115 |
| Jacksonville Jaguars (2-14) | +15.5 | +750 | U 43.5 -105 |
Though the spread and moneyline are both the same as the opening odds to begin the week, the total for the matchup was lowered by one point.
The Colts haven’t won a game in Jacksonville since 2014. Only two Colts from that team remain on the roster (T.Y. Hilton, Jack Doyle) while Frank Reich has never gotten a win in Duval County.
The Colts can still get into the playoffs with a loss but they would need some major help elsewhere.
Regardless, Vegas has the Colts as one of the biggest favorites of the week entering the weekend.
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