The Indianapolis Colts (8-6) are preparing to make a long trip across the country to the southwest, visiting the Arizona Cardinals (10-4) at State Farm Stadium in Week 16.
While the Colts are one of the hottest teams in the NFL and are coming off of a big 27-17 win over the top-seeded New England Patriots, they will open the week as slight road underdogs in Week 16, according to Tipico Sportsbook.
| Spread | Moneyline | Total Points | |
| Indianapolis Colts (8-6) | +1.5 | +102 | O 49.5 -110 |
| Arizona Cardinals (10-4) | -1.5 | -125 | U 49.5 -110 |
The Colts have won five of their last six games and seven of their last nine with those two losses coming within three points each. It has been an incredible turnaround from the 1-4 start they struggled through.
The Cardinals got off to the hottest start in the NFL with a 7-0 winning streak but are 3-4 since then. They are coming off of an embarrassing loss to the Detroit Lions, who just won their second game of the season.
Though this game doesn’t matter as much for playoff seeding, the Colts will want to do their best to come out with a win against a Cardinals offense that will look to use Kyler Murray as a game-changer.
Regardless, they have their work cut out for them in this Week 16 matchup and open the week as underdogs for the first time in a while.
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