College football picks and predictions for Week 0: Best bets for season-opening slate

The Sportsbook Wire staff makes its best bets and picks for Saturday’s college football Week 0 slate.

The 2021-22 college football season kicks off Saturday and Sportsbook Wire writers offer up their best bets on each of the five Week 0 games. The day’s action begins with the 1 p.m. ET kickoff between the Nebraska Cornhuskers and Illinois Fighting Illini. Below, we make our NCAAF picks and predictions for the College Football Week 0 slate.

Odds provided by Tipico Sportsbook and last updated Friday, Aug. 27.

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