Cleveland Guardians at Cincinnati Reds odds, picks and predictions

Analyzing Tuesday’s Cleveland Guardians at Cincinnati Reds odds and lines, with MLB expert picks and predictions.

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The Cleveland Guardians (2-2) take on the Cincinnati Reds (2-2) Tuesday at Great American Ball Park in Cincinnati. First pitch is scheduled for 4:10 p.m. Let’s analyze Tipico Sportsbook‘s lines around the Guardians vs. Reds odds with MLB picks and predictions.

The Guardians split their wraparound 4-game series against the Kansas City Royals. Cleveland won its final 2 games of the set to gain the split, outscoring Kansas City 27-10 after being outscored in the first two games 4-1.

The Reds also split a 4-game set in their opening series, playing well against the Atlanta Braves. Cincinnati scored exactly 6 runs in 3 of the 4 outings.

Guardians at Reds: Projected starters

RHP Shane Bieber vs. RHP Tyler Mahle

Bieber did not factor into the decision in his first start against Kansas City Thursday, allowing a run with 3 hits and no walks while striking out 4 across 4.2 IP.

  • Went 5-2 with a 2.91 ERA with a .211 opponent batting average in 9 road starts across 55.2 IP on the road last season.
  • Allowed 3 runs, 6 hits and 2 walks with 13 strikeouts over 8 innings in a win at GABP April 18 last season in his only appearance against the Reds.

Mahle picked up the win in his initial start of the season Thursday, allowing 1 unearned run, 3 hits and 2 walks with 7 strikeouts across 5 innings.

  • Went 5-4 with a 5.63 ERA across 78.1 IP over 15 starts at home last season, striking out 98 batters with 19 home runs allowed.
  • Last faced Cleveland Aug. 4, 2020, allowing just 1 hit and 2 walks with 6 strikeouts across 6 scoreless innings in a no-decision.

Guardians at Reds odds, spread and lines

Odds provided by Tipico Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated at 7:30 a.m. ET.

  • Money line (ML): Guardians -120 (bet $120 to win $100) | Reds +100 (bet $100 to win $100)
  • Run line (RL)/Against the spread (ATS): Guardians -1.5 (+135) | Reds +1.5 (-170)
  • Over/Under (O/U): 8.5 (O: -105 | U: -120)

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Guardians at Reds prediction and picks

Prediction

Guardians 4, Reds 2

Money line

The GUARDIANS (-120) failed to win in Bieber’s first start in Kansas City. He probably saw the offense break out in the past 2 games and wondered where the run support was in his outing. The Cleveland bats will likely struggle a little against Cincinnati’s opening-day starter, but it’ll do enough to get the win for its ace.

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Run line/Against the spread

The GUARDIANS -1.5 (+135) are worth a small-unit play in this one. In its 2 wins, Cleveland also won by 3 or more runs each time. If you like Cleveland to win, you should like it on the run line, too.

Over/Under

The UNDER 8.5 (-120) is the best play on the board in this battle between the aces of these teams. Cincinnati pitching has allowed 15 total runs across 4 games so far, while Cleveland pitching has allowed 3 or fewer runs in 3 of 4 games to date.

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