Cleveland Guardians at Chicago White Sox odds, picks and predictions

Analyzing Friday’s Cleveland Guardians at Chicago White Sox odds and lines, with MLB expert picks and predictions.

The Cleveland Guardians (46-44) open the 2nd half with a 3-game set vs. the AL Central co-tenant Chicago White Sox (46-46). Friday’s 1st pitch at Guaranteed Rate Field is scheduled for 8:10 p.m. ET. Let’s analyze Tipico Sportsbook‘s lines around the Guardians vs. White Sox odds with MLB picks and predictions.

Season series: Cleveland leads 6-3 with a plus-13 run differential in those meetings.

Cleveland ended the 1st half of its season with a 3-game sweep at home vs. the Detroit Tigers after splitting a 4-game series with the White Sox. The Guardians are 6-4 straight up (SU) in their last 10 games.

Chicago is 7-3 SU in the last 10 games, which includes winning 3 of a 4-game series with the AL Central-leading Minnesota Twins entering the All-Star break.

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Guardians at White Sox projected starters

RHP Cal Quantrill vs. RHP Lucas Giolito    

Quantrill is 6-5 with a 3.75 ERA, 1.29 WHIP, 2.7 BB/9 and 5.6 K/9 in 100 2/3 IP over 17 starts.

  • Last start: Won 10-0 at home Saturday vs. the Tigers with 6 scoreless IP, 4 H, 2 BB and 5 K.
  • 2022 vs. the White Sox: 1-1 with a 5.84 ERA (12 1/3 IP, 8 ER), 17 H, 2 HR, 1 BB and 6 K in 2 starts.

Giolito is 6-5 with a 4.69 ERA, 1.40 WHIP, 3.3 BB/9 and 10.4 K/9 in 88 1/3 IP across 16 starts.

  • Last start: Won 2-1 July 13 at the Guardians with 6 1/3 IP, 1 R (0 ER), 5 H, 1 BB and 5 K.
  • 2022 vs. the Guardians: 2-0 with a 0.68 ERA (13 1/3 IP, 1 ER), 11 H, 1 HR, 2 BB and 10 K in 2 starts.

Guardians at White Sox odds and lines

Odds provided by Tipico Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated at 8:13 a.m. ET.

  • Money line (ML): Guardians +130 (bet $100 to win $130) | White Sox -160 (bet $160 to win $100)
  • Run line (RL)/Against the spread (ATS): Guardians +1.5 (-160) | White Sox -1.5 (+130)
  • Over/Under (O/U): 8.5 (O: -115 | U: -107)

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Guardians at White Sox picks and predictions

Prediction

Guardians 5, White Sox 3

Money line

BET GUARDIANS (+130).

There’s “reverse line movement” (RLM) headed toward Cleveland in the betting market despite Quantrill’s terrible road splits and Giolito’s impressive numbers vs. the Guardians in 2022.

Also, the Guardians have a slightly better bullpen than the White Sox (-160) and Cleveland’s lineup is more productive vs. right-handed pitching than Chicago’s.

More than 80% of the money is on the White Sox per Pregame.com but the Chicago’s ML has gone from a -165 opener down to the current number and is as low as -145 on some sportsbooks.

Common sense says oddsmakers would adjust the line according to the market movement so this RLM suggests the House is baiting bettors into taking more pro-White Sox action.

Cleveland’s lineup outranks Chicago’s vs. right-handed pitching in wRC+ (107-95), wOBA (.318-.296), ISO (.147-.119) and BB/K rate (0.44-0.30), according to FanGraphs.

BET GUARDIANS (+130).

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Run line/Against the spread

PASS.

I’m not confident enough in the Guardians +1.5 (-160) to “sprinkle” on their alternate RL and Cleveland’s preflop RL is too expensive even though the White Sox -1.5 (+130) are 9-23 RL as home favorites.

Over/Under

LEAN towards the UNDER 8.5 (-107) because money is flooding in on the Over.

Also, 4 of the last 5 Guardians-White Sox meetings have gone Under the total and Chicago’s lineup ranks in the bottom of the MLB in several advanced hitting metrics vs. right-handed pitching.

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