The Clemson Tigers (7-0) head to South Bend, Ind. for a conference showdown against the Notre Dame Fighting Irish (6-0). The Irish are in the ACC for 2020 due to COVID-related circumstances. Kickoff is scheduled for 7:30 p.m. ET at Notre Dame Stadium. Below, we analyze the Clemson-Notre Dame college football betting odds and lines, with picks and predictions.
The Tigers are No. 1 in the Amway Coaches Poll powered by USA TODAY Sports, while the Fighting Irish are No. 4.
Also see: Clemson at Notre Dame prop predictions
Clemson at Notre Dame: Betting odds, spread and lines
Odds via BetMGM; access USA TODAY Sports’ betting odds for a full list. Lines last updated Saturday at 11:25 a.m. ET.
- Money line: Clemson -209 (bet $209 to win $100) | Notre Dame +170 (bet $100 to win $170)
- Against the spread/ATS: Clemson -5.5 (-110) | Notre Dame +5.5 (-110)
- Over/Under: 49.5 (O: -110 | U: -110)
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Clemson at Notre Dame: Three things to know
- QB Trevor Lawrence missed Clemson’s previous game against the Boston College Golden Eagles after testing positive for COVID Oct 28. Lawrence’s replacement—Freshman QB D.J. Uiagalelei, a five-star recruit out of Bellflower, Calif.—completed 30 of 41 passes for 342 yards and 2 touchdowns with zero interceptions and added a rushing touchdown in Clemson’s 34-28 win on Halloween.
- Notre Dame made quick work of the Georgia Tech Yellow Jackets last week, winning 31-13 but failed to cover as a 20.5-point favorite.
- According to ESPN Stats & Info, Notre Dame head coach Brian Kelly will be coaching against an AP Top-5 team for the eighth time in his career and sixth time at Notre Dame. He’s 0-7 in these games and his team has never scored more than 27 points.
Clemson at Notre Dame: Odds, betting lines, predictions and picks
Prediction
Clemson 24, Notre Dame 20
Money line (ML)
If it feels like we see Notre Dame (+170) in one of these games every year and every year the Fighting Irish come up short, well it’s because that is what usually happens.
Obviously, Clemson (-209) has also been playing and winning in these spots. The Tigers haven’t lost more than two games in a season since 2014, which is the only year they haven’t played in the College Football Playoff.
I am not betting against the Tigers here but I am also not risking more than two times my potential return for an outright win. If I was playing Clemson’s money line, I’d include it in a parlay.
Against the spread (ATS)
Both defenses can one-up each other in matchup stats. They’ve each been unbelievable this season but the Fighting Irish are at full strength whereas the Tigers will be missing several key pieces.
Clemson starting LBs James Skalski, Mike Jones Jr. and starting DT Tyler Davis will all miss Saturday’s game and DE Xavier Thomas will be suspended for the first half because of a targeting penalty in the game against Boston College.
Furthermore, since Kelly took over as head coach at Notre Dame in 2010, the Fighting Irish have a winning ATS record against ranked foes (22-20 ATS). I LEAN NOTRE DAME +5.5 because its offense could have some success in this spot.
Over/Under (O/U)
With no Lawrence in the lineup, Clemson should lean on senior RB Travis Etienne who’s having an amazing finale to his college career. Again, Notre Dame typically comes up short in big spots: The Under is 4-0 in the Fighting Irish’s last four games as a home underdog.
TAKE UNDER 49.5.
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