Defense
| Pos. | First | Second | Third |
| LDE | Alex Okafor | Demone Harris | |
| LDT | Chris Jones | Khalen Saunders | |
| RDT | Derrick Nnadi | Mike Pennel | |
| RDE | Frank Clark | Tanoh Kpassagnon | |
| LB | Anthony Hitchens | Ben Niemann | Reggie Ragland |
| LB | Damien Wilson | Darron Lee | Dorian O’Daniel |
| LCB | Charvarius Ward | Rashad Fenton | Mo Claiborne |
| RCB | Bashaud Breeland | Rashad Fenton | |
| CB | Kendall Fuller | Rashad Fenton | |
| FS | Juan Thornhill | Daniel Sorensen | |
| SS | Tyrann Mathieu | Jordan Lucas | Armani Watts |
Observations:
- Emmanuel Ogbah had season-ending surgery on a torn pectoral muscle. He was sent to the injured reserve list in order to make room for Gehrig Dieter in Week 11.
- Joey Ivie was released in order to make room for defensive end Demone Harris, who came from the Ravens practice squad. The Chiefs seem to like having four true defensive ends on the roster as part of the rotation. Harris will fill the second-string DE spot vacated by Ogbah.