Chicago White Sox at Minnesota Twins odds, picks and predictions

Analyzing Friday’s Chicago White Sox at Minnesota Twins odds and lines, with MLB expert picks and predictions.

The Chicago White Sox (44-45) continue their 4-game series with the Minnesota Twins (49-42) at Target Field Friday with the 1st pitch set for 7:40 p.m. ET. Let’s analyze Tipico Sportsbook‘s lines around the White Sox vs. Twins nickname odds with MLB picks and predictions.

Chicago hammered Minnesota 12-2 in Thursday’s series opener, but the Twins lead the season series 5-2 with a plus-8 run differential.

The White Sox are 6-4 straight up (SU) in their last 10 games and sit 4 games behind the Twins for 1st-place in the AL Central. Minnesota is just 4-6 SU in the last 10.

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White Sox at Twins projected starters

RHP Michael Kopech vs. LHP Devin Smeltzer

Kopech is 2-6 with a 3.35 ERA, 1.14 WHIP, 4.4 BB/9 and 8.3 K/9 in 78 IP over 16 starts.

  • Last start: No-decision in Chicago’s 4-2 home win vs. the Detroit Tigers Sunday with 5 1/3 IP, 2 ER, 4 H, 1 HR, 3 BB and 4 K.
  • 2022 vs. the Twins: 0-1 with a 5.59 ERA (9 2/3 IP, 6 ER), 11 H, 4 HR, 5 BB and 12 K in 2 starts.

Smeltzer is 4-3 with a 3.92 ERA, 1.16 WHIP, 2.3 BB/9 and 5.4 K/9 in 59 2/3 IP over 11 starts.

  • Last start: No-decision in Minnesota’s 9-7 loss at the Texas Rangers Saturday with 3 1/3 IP, 7 ER, 8 H, 3 HR, 3 BB and 2 K.
  • 2022 home splits: 2-1 with a 2.10 ERA (30 IP, 7 ER), 0.83 WHIP, 6 HR and 5.1 K/9 in 5 starts.

White Sox at Twins odds and lines

Odds provided by Tipico Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated at 2:11 p.m. ET.

  • Money line (ML): White Sox +115 (bet $100 to win $115) | Twins -140 (bet $140 to win $100)
  • Run line (RL)/Against the spread (ATS): White Sox +1.5 (-180) | Twins -1.5 (+145)
  • Over/Under (O/U): 8.5 (O: -135 | U: +110)

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White Sox at Twins picks and predictions

Prediction

Twins 5, White Sox 2

Money line

LEAN TWINS (-140) because they are the “sharp” play and have been steamed up from a -130 ML opener, according to Pregame.com.

For instance, more than 60% of the bets placed are on the White Sox (+110) but roughly two-thirds of the money is on the Twins, per Tipico Sportsbook. Typically, it’s wise to follow the cash when it’s counter to the public since professional bettors put up a lot more dough than your average Joe.

However, it’s just a LEAN to the TWINS (-140) because the market analysis is my only handicapping here and the Under is my favorite look in this game.

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Run line/Against the spread

PASS.

I’m not confident enough in the Twins -1.5 (+145) to “sprinkle” on their RL and they are just 14-20 RL as home favorites whereas the White Sox +1.5 (-180) are 17-9 RL as road underdogs.

Over/Under

BET a half-unit on the UNDER 8.5 (+110).

The White Sox are 5-9-2 O/U in Kopech’s road outings with a plus-20.5% return on investment (ROI)  towards the Under and an average total of 7.80. The Twins are 1-4 O/U in Smeltzer’s home starts with a plus-53.6% ROI and an average total of 5.60.

Wait closer to the first pitch in hopes of getting a 9- or 9.5-run total but I’d WAGER a half-unit on the UNDER 8.5 (+110).

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