The Chicago White Sox (6-3) face the Cleveland Guardians (4-5) Tuesday in the opener of what is now a three-game set. First Pitch from Progressive Field in Cleveland is scheduled for 6:10 p.m. ET (ESPN+). Let’s analyze Tipico Sportsbook‘s lines around the White Sox vs. Guardians odds with MLB picks and predictions.
Season series: White Sox won the 2021 series 10-9
These teams were expected to open a four-game set Monday, but a chilly rain/snow mix washed out the opener which has been rescheduled for July 12. The White Sox won five of the nine meetings in Cleveland last season.
The Guardians opened the season with wins in four of their first six games — all on the road — but were swept in a three-game interleague set against the San Francisco Giants over the weekend, so they’re still looking for the first home win of 2022.
White Sox at Guardians: Projected starters
LHP Dallas Keuchel vs. RHP Shane Bieber
Keuchel (1-0, 5.40 ERA) makes his second start. He allowed 3 ER on 6 H and 0 BB with 5 K across 5 IP in his first start versus the Seattle Mariners Wednesday.
- Posted a 4-7 record and 5.75 ERA with a .310 opponent batting average across 81 1/3 IP in 16 road starts in 2021.
- Managed a 0-1 record, 6.61 ERA and 4 home runs allowed in just 16 1/3 IP across three starts versus Cleveland last season.
Bieber (0-0, 2.70 ERA) allowed 3 ER on 2 H and 3 BB with 5 K in 5 1/3 IP at the Cincinnati Reds in his second start of the season last Tuesday. This will be his first home outing of 2022.
- Went 2-2 with a 3.51 ERA with 53 strikeouts over 41 IP across seven starts at Progressive Field in 2021.
- Managed a tremendous 3-0 record, 1.80 ERA and .169 OBA with 32 K and no HR allowed across 25 IP in four starts against the White Sox last season.
White Sox at Guardians odds and lines
Odds provided by Tipico Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated at 7:20 a.m. ET.
- Money line (ML): White Sox +120 (bet $100 to win $120) | Guardians -145 (bet $145 to win $100)
- Run line (RL)/Against the spread (ATS): White Sox +1.5 (-180) | Guardians -1.5 (+145)
- Over/Under (O/U): 7.5 (O: -115 | U: -107)
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White Sox at Guardians picks and predictions
Prediction
Guardians 4, White Sox 2
Money line
The GUARDIANS (-145) are worth playing as moderate favorites at home. The home side caught a break with the weather Monday, as they’ll now be able to use their ace for this series opener.
While Cleveland hasn’t really supported its Opening Day starter with a lot of offense, he’ll break through against a team he showed well against in 2021.
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Run line/Against the spread
GUARDIANS -1.5 (+145) are worth playing very lightly on the run line. Bieber had a tremendous hold on the White Sox last season, racking up three of his seven victories against the Pale Hose. The offense has struggled a bit lately after flying high in Kansas City and Cincinnati, so be careful.
Over/Under
The UNDER 7.5 (-107) might be the best play on the board here.
The Under is 5-1 in the past six games for the ChiSox against a right-handed starting pitcher, while going 7-2-1 in the past 10 as an underdog going back to last season. The Under is also 11-5-1 in the past 17 road games for Chicago.
While the Over is 5-2 in the past seven for Cleveland, the Under is 5-2 in the past seven at Progressive Field, including 2-1 this season. Cleveland’s offense scratched out just 4 total runs in the three-game sweep at the hands of San Francisco.
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