Carolina Panthers at New York Giants odds, picks and predictions

Analyzing Sunday’s Carolina Panthers at New York Giants odds and lines, with expert NFL picks, predictions and best bets.

The Carolina Panthers (0-1) and the New York Giants (1-0) meet in a Week 2 matchup Sunday at MetLife Stadium. Kickoff is scheduled 1 p.m. ET (FOX). Below, we analyze Tipico Sportsbook‘s lines around the Panthers vs. Giants odds, and make our expert NFL picks and predictions.

The Panthers had a chance to win last week against the Cleveland Browns, but allowed a 58-yard game-winning field goal in the final 10 seconds to come up just a little bit short at home, 26-24.

Down 20-13, the Giants scored a late touchdown to make it 20-19, pending the extra point. Head coach Brian Daboll — in his debut in that role – ended up calling for the 2-point conversion and RB Saquon Barkley got it done. The Titans missed a field goal at the buzzer, and the Giants held on for the solid 21-20 road win as the Under cashed.

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Panthers at Giants odds

Provided by Tipico Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated Friday at 8:06 a.m. ET.

  • Money line (ML): Panthers +110 (bet $100 to win $110) | Giants -130 (bet $130 to win $100)
  • Against the spread (ATS): Panthers +2.5 (-110) | Giants -2.5 (-110)
  • Over/Under (O/U): 43.5 (O: -112 | U: -108)

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Panthers at Giants key injuries

Panthers

  • LB Frankie Luvu (shoulder) questionable
  • OL Taylor Moton (knee) questionable
  • LB Brandon Smith (thigh) questionable

Giants

  • Joe Fellciano (lower leg) questionable
  • DL/LB Azeez Ojulari (calf) questionable
  • CB Aaron Robinson (appendicitis) questionable
  • WR Wan’Dale Robinson (knee) questionable
  • LB Kayvon Thibodeaux (knee) questionable
  • WR Kadarius Toney (hamstring) questionable

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Panthers at Giants picks and predictions

Prediction

Giants 27, Panthers 24

Money line

The GIANTS (-130) aren’t a bad play if you don’t want to fiddle around with the points, and just want to declare a winner. It isn’t that much more juice to take the home side.

The G-Men established the run last week, as Barkley is finally 100 percent and looks like his former self. The Giants won 25-3 last season against the Panthers without Barkley, while RB Christian McCaffrey also missed that meeting. CMC is back, too, and this game should be a lot more interesting.

Against the spread

GIANTS -2.5 (-110) is a strong play on their home field. This team won by 22 against a McCaffrey-less Panthers offense last season. Carolina’s offense should be much better, especially with QB Baker Mayfield now in the fold, but it won’t have enough to upend Barkley and the Giants on the road.

Over/Under

The OVER 43.5 (-112) might be the best play on the board. McCaffrey and Barkley are both playing in this game after missing last season’s matchup. The run game is obviously better with them on the field, but that opens things up more downfield in the pass game, too.

Expect to see a lot more fireworks in this battle in New Jersey, with the Giants coming out ahead late.

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