Carolina Panthers at Indianapolis Colts odds and lines: Banged-up Colts still favored

Analyzing the NFL preseason Week 1 odds and lines as the Carolina Panthers take on the Indianapolis Colts

The Carolina Panthers and Indianapolis Colts will wrap up the first week of the preseason Sunday at 1 p.m. ET from Lucas Oil Stadium. Below, we look at the Panthers at Colts odds and lines.

The Panthers struggled mightily last season without RB Christian McCaffrey for most of the year, limping to a 5-11 record. McCaffrey will be back this season but Carolina will likely take it slow with the electric running back. QB Sam Darnold takes over under center after an offseason trade, hoping to provide a spark on offense and take some pressure off of McCaffrey to carry the load.

The Colts suffered a major blow in training camp when both QB Carson Wentz and G Quenton Nelson underwent foot surgery, which will keep them both out 5-12 weeks. The defense still looks like it could be one of the best in the league, led by LB Darius Leonard and DT DeForest Buckner, but there are now questions about the offense with two critical players sidelined.

Panthers at Colts: Odds, spread and line

Odds via Tipico Sportsbook; access USA TODAY Sports’ betting odds for a full list. Lines last updated Monday at 5:52 p.m. ET.

  • Money line: Panthers +100 (bet $100 to win $100) | Colts -125 (bet $125 to win $100)
  • Against the spread/ATS: Panthers +1.5, -105 (bet $105 to win $100) | Colts -1.5, -115 (bet $115 to win $100)
  • Total: 34.5, Over -115 (bet $115 to win $100) | Under -105 (bet $105 to win $100)

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2020 Betting stats:

  • ATS: Panthers 9-7 | Colts 9-8
  • O/U: Panthers 7-9 | Colts 10-7

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The Panthers are slight underdogs with a money line of +100, which has an implied probability of 50%. A $10 wager on Carolina to win outright would return a profit of $10. The Colts money line is -125, which means a $10 wager would return a profit of $8.

When it comes to the spread, the Panthers are +1.5, meaning they have to win outright, tie or lose by no more than 1 point to cover the spread. A $10 bet on the Panthers to cover would net a profit of $9.52. The Colts must win by 2 or more points to cover the spread, with a $10 wager on Indianapolis returning a profit of $8.70.

The Over/Under is set at 34.5 points. If the Panthers and Colts combine for 35 or more points, the Over would return a profit of $8.70 on a $10 bet. If the total goes Under 34.5 points, a $10 bet would win $9.52.

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