The 49ers are very banged up, especially on offense. What is the most likely lineup they are going to play on Sunday, and what will the offense look like with that group?

Ross Dwelley will start at tight end with Kittle out. Matt Breida is also doubtful, which means more carries for Tevin Coleman and Raheem Mostert. Jeff Wilson Jr. could also see some work in short-yardage situations. Sanders should play, but I’m expecting a lot of Kendrick Bourne and perhaps some more Richie James than usual. Joe Staley is also out, so it’ll be Justin Skule, who started at left tackle last time these teams faced off. The 49ers simply can’t throw as effectively when Kittle isn’t in the game, and if Sanders is on a snap count, their passing attack becomes nonexistent. We saw that Monday against Seattle, and it would probably happen again Sunday. I’m expecting a heavy dose of the rushing attack to try and open the playbook on play-action and some throws down the field.

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