Buffalo Bills at New England Patriots odds, picks and predictions

The Buffalo Bills (13-3) visit the New England Patriots (3-13) Sunday afternoon. Kickoff from Gillette Stadium is scheduled for 1 p.m. ET (CBS). Let’s analyze BetMGM Sportsbook’s NFL odds around the Bills vs. Patriots odds, and make our expert NFL …

The Buffalo Bills (13-3) visit the New England Patriots (3-13) Sunday afternoon. Kickoff from Gillette Stadium is scheduled for 1 p.m. ET (CBS). Let’s analyze BetMGM Sportsbook’s NFL odds around the Bills vs. Patriots odds, and make our expert NFL picks and predictions.

The Bills have won 3 games in a row after throttling the Jets 40-14 on Sunday and covering as 10.5-point home favorites, and clinching the AFC’s No. 2 seed. QB Josh Allen went 16 of 27 for 182 yards with 2 touchdowns while adding another on the ground in the win. With no further playoff implications, Buffalo is expected to rest most starters except Allen, who will play to continue his 114-game starting streak. He’s not expected to play much, though.

The Patriots have dropped 6 games in a row after being decimated 40-7 against the Chargers last Saturday and failing to cover as 6-point home underdogs. QB Drake Maye went 12 of 22 for 117 yards and a TD in the loss.

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Bills at Patriots odds

Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list of NFL odds. Lines last updated Saturday at 11:45 a.m. ET.

  • Moneyline (ML): Bills -190 (bet $190 to win $100) | Patriots +155 (bet $100 to win $155)
  • Against the spread (ATS): Bills -3.5 (-110) | Patriots +3.5 (-110)
  • Over/Under (O/U): 36.5 (O: -110 | U: -110)

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Bills at Patriots key injuries

Bills

  • LB Terrel Bernard (quadricep) out
  • WR Curtis Samuel (rib) questionable

Patriots

  • Ben Brown (concussion) out
  • Kyle Dugger (ankle, quadricep) questionable
  • CB Christian Gonzalez (concussion) out
  • TE Hunter Henry (foot) questionable
  • LB Anfernee Jennings (knee) questionable
  • DE Titus Leo (ankle) questionable
  • QB Drake Maye (right hand) questionable
  • Jabrill Peppers (hamstring) out
  • WR Ja’Lynn Polk (shoulder) out
  • LB Sione Takitaki (knee) questionable

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Bills at Patriots picks and predictions

Prediction

Bills 24, Patriots 13

Moneyline

PASS.

There is minimal value on the Bills (-190) to handle the Patriots, who are in position to get the No. 1 pick in the 2025 draft with a loss Sunday.

Against the spread

BET BILLS -3.5 (-110).

Even without a majority of its starters, Buffalo is a dominant team. With Allen at least starting, Buffalo will not struggle too much against a New England team that has something to lose for. Buffalo is 10-6 against the spread (ATS) this season compared to New England’s 6-9-1 ATS record.

Over/Under

LEAN OVER 36.5 (-110).

While there are no playoff implications in this matchup, the players are still playing for their jobs and future jobs looking ahead to the offseason. Both teams will still look to be aggressive. With the Pats entering this matchup with a plethora of injuries, Buffalo will look to close out its season with a solid performance.

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For more sports betting picks and tips, check out SportsbookWire.com and BetFTW.

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