Buffalo Bills at Las Vegas Raiders odds, picks and best bets

Previewing the Buffalo Bills at Las Vegas Raiders Week 4 betting odds, spread and lines, with NFL betting picks, tips and best bets.

The Buffalo Bills (3-0) and Las Vegas Raiders (2-1) meet at Allegiant Stadium in Las Vegas in Week 4. Kickoff is Sunday at 4:25 p.m. ET (on CBS). Here, we analyze the Bills-Raiders Week 4 matchup, including the betting odds, spread and lines, and look at the best NFL betting options.

Bills at Raiders betting odds and lines

Odds via BetMGM; access USA TODAY Sports’ betting odds for a full list. Lines last updated Saturday at 9:05 a.m. ET

  • Money line: Bills -179 (Bet $179, win $100) | Raiders +150 (Bet $100, win $150)
  • Against the spread/ATS: Bills -3.5 (-110) | Raiders +3.5 (-110)
  • Over/Under: 52.5 (O: -110 | U: -110)

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Bills at Raiders game notes

  • The Bills enter this game with at least 27 points scored in every game this season, while their defense is yielding 25.7 points per game. Last season, the Bills led the NFL with 12 Under results in 16 games, but the Over is a perfect 3-0 in 2020.
  • One area where Buffalo has struggled is running the ball, as it has posted just 103.7 yards per game on the ground to rank 24th. The Bills are also 28th against the pass, yielding 274.7 yards per game through the air.
  • Buffalo is 2-0 straight up/ATS in two games at home, but it failed to cover in its only road outing, a 31-28 victory against the Miami Dolphins as 5.5-point favorites.
  • The Raiders have also hit the Over in each of their three games, averaging 29.3 PPG to rank eighth in the NFL while allowing 30.0 PPG to check-in 25th in the league.
  • Las Vegas has been the home team just once this season, a 34-24 win on Monday Night Football in Week 2 over the New Orleans Saints, winning outright as a four-point underdog.

Bills at Raiders key injuries

Bills

  • DE Mario Addison (knee) questionable
  • RB Zack Moss (toe) questionable

Raiders

  • S Johnathan Abram (shoulder/thumb) questionable
  • CB Damon Arnette (wrist/thumb) out
  • OT Trent Brown (calf) doubtful
  • WR Bryan Edwards (foot/ankle) out
  • LB Nick Kwiatkoski (pectoral) questionable
  • WR Henry Ruggs III (knee/hamstring) doubtful

Bills at Raiders: Odds, betting lines, picks and prediction

Prediction

Bills 31, Raiders 23

Money line (?)

The Raiders (+150) would be a sharp play at home, but they’re just too banged up in the skill positions. QB Derek Carr‘s top wideouts figure to be Hunter Renfrow, Zay Jones and Nelson Agholor. Perhaps Jones plays with a little more intensity against his former team, but that’s not exactly a who’s who. The Bills (-179) are also just a little too high in chalk for my taste, so look to the line. AVOID.

Against the spread (?)

The BILLS -3.5 (-110) are worth a light play here. Yes, they failed to cover in their only road contest this season, and I’d feel better if this were maybe -2.5 instead.

It can still be bet confidently knowing the Raiders +3.5 (-110) are decimated at receiver, and if the Bills D takes TE Darren Waller out with double teams, Vegas might have trouble moving the ball.

Over/Under (?)

The OVER 52.5 (-110) is worth a look, but like the spread, I’d go lightly on this one. The Over has hit in each of the three games for both teams so far, but the books are bumping up the total each week and the value just isn’t there.

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