Best NFL underdog picks and predictions for Week 5

Analyzing NFL Week 5 betting odds and lines, with expert predictions and picks of the 3 best underdogs to cash in on.

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In Week 4, 7 underdogs won their games outright and 10 covered the spread. Our recommended picks went 2-1, as the New York Giants covered the spread in a 20-15 loss to the Dallas Cowboys thanks to a missed field goal in the final minutes and the Jacksonville Jaguars covered the spread in a 24-20 setback to the Houston Texans. The LA Rams did not hold up their end of the bargain, losing 24-18 to the Chicago Bears as 3-point underdogs.

We are 6-5-1 with our picks through 4 weeks.

Below, we analyze BetMGM Sportsbook NFL odds and tab the best NFL Week 5 underdog bets to cash in on among SportbookWire’s NFL expert picks and predictions.

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NFL underdog predictions: Week 5

Odds provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list of NFL odds. Lines last updated Thursday at 11:10 a.m. ET. All games Sunday and ET unless noted.

BUCCANEERS (+105) at Falcons – Thursday, 8:15 p.m. (Prime Video)

The Tampa Bay Buccaneers have scored over 30 points twice this season. They have 3 good wins over the Washington Commanders, Philadelphia Eagles and Detroit Lions.

The Atlanta Falcons have allowed over 20 points in 3 straight games.

Both teams have a win over the Eagles. Atlanta barely won. The Bucs blew them out.

Atlanta has not covered the spread as a favorite yet this season.

Buccaneers QB Baker Mayfield threw 2 TD passes and rushed for another last week.

Atlanta will struggle to keep up with Tampa Bay’s offense, and only 1 team has scored more than 20 points on Tampa Bay’s defense

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COLTS +3 (-115) at Jaguars – 1 p.m. (CBS)

The Jags almost came through with a win against Houston but gave up a late game-winning touchdown. Now they face an Indianapolis Colts team that might be without both QB Anthony Richardson and RB Jonathan Taylor. But it was QB Joe Flacco that led the Colts to a win last week. He has won the last 5 regular-season games he has started or gotten significant playing time in. The Colts scored 27 on the Pittsburgh Steelers defense.

Jacksonville’s best offensive performance this season has been 20 points.

The Colts have scored more than that 3 times this season.

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RAIDERS (+125) at Broncos – 4:05 p.m. (FOX)

That Denver Broncos defense has been tremendous, allowing 9.7 points per game over the last 3 contests. But how many times can you win when your starting quarterback has 60 passing yards (like Bo Nix had in the Broncos’ 10-9 win over the New York Jets)?

The Las Vegas Raiders have won the last 8 meetings. They have scored 20 or more points in 3 straight games.

Don’t trust the Broncos to win 3 games in a row as currently constructed.

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For more sports betting picks and tips, check out SportsbookWire.com and BetFTW.

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