Best NFL underdog picks and predictions for Week 4

[gambcom-standard rankid=”3011″ ]

There were multiple unexpected upsets in Week 3. The Arizona Cardinals, Houston Texans and Indianapolis Colts, all underdogs by at least a touchdown, beat their heavily favored opponents outright.

There were 5 outright underdog winners in Week 3. No others covered the spread without winning. Our 3 underdog picks were duds last week, bringing our running season record to 6-3.

Below, we analyze BetMGM Sportsbook NFL odds and lines, and tab the best NFL Week 4 underdog bets to cash in on among SportbookWire’s NFL expert picks and predictions.

FOOTBALL NEVER STOPS
Live games, analysis and more 7 days a week: Get ESPN+

NFL underdog predictions: Week 4

Odds provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated Thursday at 10:22 p.m. ET. All games Sunday and ET unless noted.

CARDINALS +14 (-110) at 49ers – 4:25 p.m. (FOX)

The Cardinals pulled off 1 of the more unlikely upsets last week, beating the Dallas Cowboys 28-16 as 11-point underdogs. They have covered the spread in every game and held a halftime lead in all 3. They don’t fall far behind in games and have not turned the ball over in their last 2 games.

Is it likely they beat a very disciplined 49ers team? No, but 14 points is a lot to give to them after they did what they did to the Cowboys, scoring on 5 straight possessions against a team that had allowed only 10 points total previously.

[gambcom-standard rankid=”3012″ ]

RAMS +1 (-115) at Colts – 1 p.m. (FOX)

OK, this is a case of why are the Colts favored? Yes, they beat the Ravens last week in overtime and the Rams lost to the Bengals Monday night, but QB Matthew Stafford has passed for more than 300 yards twice in 3 games.

Colts rookie QB Anthony Richardson should return to the lineup after missing a game and a half. The Colts won without him. Were it QB Gardner Minshew getting the start, I would like the Colts more.

SEAHAWKS -1 (-110)-* at Giants – Monday, 8:15 p.m. (ESPN, ABC)

*-The line has bounced back and forth. The Giants were favored Thursday morning, but now the Seahawks are a small favorite.

The Giants have played only 2 good quarters in 3 games, when they put up 31 points on the Cardinals in the 2nd half in Week 2. They had 171 yards in Week 1 and 150 in Week 3. They have allowed 32.7 points per game.

The Seahawks have put up 37 points in each of the last 2 weeks.

Others to consider

Buccaneers +3.5 (-115) at Saints is another solid choice because the Saints likely will be without QB Derek Carr, who injured his shoulder last week.

Packers (+115) over the Lions at home on Thursday night is also a fun choice because of the play of QB Jordan Love.

Play our free daily Pick’em Challenge and win! Play now!

[gambcom-standard rankid=”5″ ]

For more sports betting picks and tips, check out SportsbookWire.com and BetFTW.

Follow Jess Root on Twitter/X. Follow SportsbookWire on Twitter/X and like us on Facebook.

Access more NFL coverage:

[lawrence-newsletter]

[lawrence-auto-related count=3 category=1367]