The Baltimore Orioles (43-44) and Chicago Cubs (34-52) meet Tuesday on Chicago’s North Side for the opening of a 2-game interleague set at Wrigley Field. First pitch is scheduled for 8:05 p.m. ET. Let’s analyze Tipico Sportsbook‘s lines around the Orioles vs. Cubs odds with MLB picks and predictions.
Season series: Baltimore leads 1-0.
The Orioles arrive in Chicago with an 8-game win streak in tow. Baltimore is 19-11 over its last 30 games.
The Cubs are an inverse 11-19 over their last 30. Albeit in close games — all by 1 or 2 runs — Chicago has lost 4 in a row.
Orioles at Cubs projected starters
RHP Jordan Lyles vs. RHP Adrian Sampson
Lyles (5-7, 4.50 ERA) is tabbed for his 18th start of the season. He has a 1.40 WHIP, 2.8 BB/9 and 7.4 K/9 through 98 IP.
- Has fared much better at home than on the road. Owns a 2.72 ERA at Camden Yards and a 5.89 mark abroad.
- Typically gets fairly deep into games. Has given the O’s 6 IP or more in 4 straight starts.
Sampson (0-0, 2.91 ERA) owns a 1.02 WHIP, 1.2 BB/9 and 7.9 K/9 through 21 2/3 IP across 3 starts and 2 relief appearances.
- Coming off yielding 1 run in 5 2/3 IP at the Milwaukee Brewers Wednesday.
- Has allowed 7 ER in 16 IP as a starter this season.
- Has logged a 4.93 career ERA with starts accounting for half of his 56 games.
Orioles at Cubs odds and lines
Odds provided by Tipico Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated 8:58 a.m. ET.
- Money line: Orioles +100 (bet $100 to win $100) | Cubs -120 (bet $120 to win $100)
- Run line (RL): Orioles +1.5 (-200) | Cubs -1.5 (+160)
- Over/Under (O/U): 8.5 (O: -130 | U: +105)
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Orioles at Cubs picks and predictions
Prediction
Cubs 4, Orioles 3
Money line
Leaning into streaks of 3-plus games either way is sometimes best done in small doses, so consider a partial-unit play on Chicago.
Its a play angling into Baltimore being a bit overrated right now and a Cubs relief corps being due for better days.
TAKE CHICAGO (-120) but pass if this tag gets any heavier.
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Run line/Against the spread
Avoid the hefty juice toll: PASS.
Over/Under
Both clubs carry in some mixed signals when it comes to runs scored and allowed. The Cubs bullpen zags against its surface numbers (4.45 ERA) and puts a green check in the Under column.
Baltimore’s recent run production isn’t fully supported by a strong OPS. The Orioles are coming off an undefeated home stand that saw them bat .344 (with a .489 batting average on balls in play) with runners in scoring position.
BACK THE UNDER 8.5 (+105).
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