Arizona Cardinals at Seattle Seahawks odds, picks and prediction

Previewing the Arizona Cardinals at Seattle Seahawks Week 11 betting odds and lines, with NFL betting picks, tips and predictions.

The Arizona Cardinals (6-3) and Seattle Seahawks (6-3) kick off Week 11 in the NFL with an NFC West showdown with playoff implications on Thursday Night Football. Kickoff is at 8:20 p.m. at CenturyLink Field in Seattle. Below, we preview the Cardinals-Seahawks betting odds and lines and make our NFL picks and predictions.

Cardinals at Seahawks: Betting odds, spread and lines

Odds via BetMGM; access USA TODAY Sports’ betting odds for a full list. Lines last updated Thursday at 7:05 a.m. ET.

  • Money line: Cardinals +140 (bet $100 to win $140) | Seahawks -162 (bet $162 to win $100)
  • Against the spread/ATS: Cardinals +3 (-115) | Seahawks -3 (-106)
  • Over/Under: 57.5 (O: -110 | U: -110)

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Cardinals at Seahawks: Game notes

  • The Cardinals have the league’s No. 1 offense in terms of yards, gaining 425.4 total yards per contest.
  • The Seahawks are the league’s top-scoring team with an average of 32.2 points scored per game.
  • Seahawks QB Russell Wilson has a league-leading 28 touchdown passes this season, but was intercepted by the Cardinals three times in Week 7 and has thrown multiple interceptions in three of his last four games.
  • Seattle has lost three of its last four games, allowing 34.66 points per game in those three losses.
  • Cardinals QB Kyler Murray has 17 touchdown passes and 10 rushing touchdowns this season and has had at least one of each in eight of nine games this year.

Cardinals at Seahawks: Key injuries

Cardinals

  • OL Justin Murray (hand) out
  • DL Corey Peters (knee) out
  • DL Jordan Phillips (hamstring) out
  • LB De’Vondre Campbell (calf) questionable
  • TE Darrell Daniels (ankle) questionable
  • Charles Washington (groin) questionable
  • TE Maxx Williams (ankle) questionable

Seahawks

  • WR Tyler Lockett (knee) questionable
  • CB Quinton Dunbar (knee) out
  • CB Shaquill Griffin (hamstring) out
  • RB Chris Carson (foot) questionable
  • OL Ethan Pocic (concussion) out
  • CB Neiko Thorpe (core) out/IR
  • Jordan Simmons (calf) out
  • RB Travis Homer (knee, thumb) doubtful

Cardinals at Seahawks: Odds, betting lines, predictions and picks

Prediction

Cardinals 33, Seahawks 27

Money line (?)

Both teams have the same record but Arizona has had uncanny success in Seattle, losing only once there since 2013. Seattle’s defense is bad to begin with and depleted with injuries, while the Cardinals offense is healthy and is able to move the ball against anyone.

Arizona is also 3-0 straight up as underdogs this season, so go with that trend. Take CARDINALS (+140).

Against the spread (?)

The Cardinals have been money as underdogs. They have covered the spread and won outright all three games this season in which they were underdogs. Seattle is a respectable 4-3 ATS as the favorites, but they are playing too poorly on defense against a potent Cardinals attack.

Take CARDINALS +3 (-115).

Over/Under (?)

The Cardinals had their first six games go Under the projected point total to start the season, but they have gone Over in each of their last three contests. The last Cardinals-Seahawks game went Over and Seattle is 6-3 O/U. This feels like a lock. Take OVER 57.5 (-110).

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