The Arizona Cardinals (6-6) are on the road this weekend to take on the NFC East-leading New York Giants (5-7). Kickoff is Sunday at 1 p.m. ET at MetLife Stadium.
Below, we preview the Cardinals-Giants betting odds and lines and make our NFL picks and predictions.
Cardinals at Giants: Betting odds, spread and lines
Odds via BetMGM; access USA TODAY Sports’ betting odds for a full list. Lines last updated Friday at 2:50 a.m. ET.
- Money line: Cardinals -135 (bet $135 to win $100) | Giants +115 (bet $100 to win $115)
- Against the spread/ATS: Cardinals -2.5 (-115) | Giants +2.5 (-105)
- Over/Under: 44.5 (O: -115 | U: -105)
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Cardinals at Giants: Game notes
- The Giants are riding a four-game winning streak.
- The Cardinals have lost three in a row and four of five.
- After five straight games of at least 30 points and 400 yards, the Cardinals have averaged 22 points per game in their last three contests and haven’t gained more than 314 yards.
- The Giants have the No. 9 scoring defense, giving up 22.1 points per game, and are ranked 10th in total defense.
- Cardinals QB Kyler Murray has 22 touchdown passes and 10 rushing touchdowns this season.
Cardinals at Giants: Key injuries
Cardinals
- WR DeAndre Hopkins (neck, back) questionable
- RB Kenyan Drake (hip) questionable
- LB De’Vondre Campbell (ankle) questionable
- LB Isaiah Simmons (neck, back) questionable
- S Jalen Thompson (ankle) out
- CB Johnathan Joseph (neck) questionable
Giants
- QB Daniel Jones (hamstring) questionable
- LB Blake Martinez (back) questionable
Cardinals at Giants: Odds, betting lines, predictions and picks
Prediction
Cardinals 24, Giants 17
Money line (?)
The Giants are on a roll and the Cardinals are in a bit of a tailspin. However, as tough as the Giants’ defense has been, they probably won’t be able to match the five sacks they had against Seattle when they play the Cardinals.
Arizona’s offense has been too good for most of the season to stay in this funk. With the Cardinals getting healthy on the defensive line, the Giants will have a harder time running the ball. Take the CARDINALS (-135).
Against the spread (?)
The short spread makes wagering against your money line pick prohibitive. The Giants are a strong 8-4 ATS while Arizona has fallen to 5-7 ATS after a very good start to the season.
But, that Arizona offense won’t stay down forever and if Drake is not 100%, RB Chase Edmonds has been very good in two career games at MetLife Stadium. He has scored four touchdowns in two games and has 242 total yards from scrimmage in those games. Take the CARDINALS -2.5 (-115).
Over/Under (?)
As good as the Cardinals’ offense was for most of the season, they are only 4-8 O/U. New York is 3-9 O/U. Arizona will not be able to get 30 against that tough Giants defense, but the New York offense struggles. Don’t expect a ton of points in this game.
Take the UNDER 44.5 POINTS (-105).
Want action on this NFL game? Sign up and bet at BetMGM. If you’re looking for more sports betting picks and tips, visit SportsbookWire.com. Please gamble responsibly.
Also see:
- Kliff Kingsbury: Cardinals need to be better with basic offensive concepts (Cards Wire)
- Giants will square off with several former friends in Week 14 (Giants Wire)
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